This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
In order to READ Online or Download Target ebooks in PDF, ePUB, Tuebl and Mobi format, you need to create a FREE account. We cannot guarantee that Target book is in the library, But if You are still not sure with the service, you can choose FREE Trial service. READ as many books as you like (Personal use).
|Book Title||: A Guide for Delineation of Lymph Nodal Clinical Target Volume in Radiation Therapy|
|Author||: Giampiero Ausili Cefaro|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2008-08-26|
|Available Language||: English, Spanish, And French|
This book will facilitate the understanding of cross-sectional anatomy details and assist radiation oncologists in the difficult task of a detailed delineation of lymph node targets in multiple anatomical locations.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
Goals, targets and objects are ideal ways to stretch individuals and develop an organization. A common misconception however is that it is very difficult, if not impossible, to set targets for certain jobs and roles. Firmly based on leading-edge research, yet highly practical in focus, Target Setting and Goal Achievement shows how it is possible to set targets in all functions of an organization and in all sectors. Clear guidelines are supported by real examples and detailed case studies as the authors outline step-by-step advice to help:
This publication is based on the plant processes and reaction sites for which reliable knowledge on both their physiology and biochem-istry and the mode of herbicidal action is available. Targets of the agrochemical research, such as enzymes of biosynthetic pathways or herbicide-binding peptides in the photosynthetic membrane, are highlighted. Detailed knowledge about the target sites will allow bio-chemical model systems to evaluate the biological activity of newly synthesized compounds before their conventional screening in the greenhouse. Quantitative structure/activity relationships should be performed more reliably with simple biological species or enzymol-ogy assays, to aid in the rational design of pesticides. This text is highly valuable for plant physiologists, pathologists, and chemists in the agrochemical industry and universities.
Annotation These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.
Compiling practical recommendations gleaned from more than 20 years of professional experience, Target Costing: Market Driven Product Design provides numerous examples from field authorities that illustrate valuable concepts and approaches employed in the application of target costing to large-scale manufacturing operations. The authors discuss setting the target product level and subsystem level, maintaining competitive costs, applying the principles of target costing in practice, and quantifying customers' needs.
This book explores the relevance that second language research has for the secondary foreign language classroom. It analyses the concept of teaching and learning exclusively through the target language. This concept is then related to two current pedagogical tendencies: peer collaboration and learner autonomy.
Presents a collection of lessons to prepare students to take the TOEIC exam.
- Definitions and interpretation - Engineer and Engineer's Representative - Assignment - Sub-contracting - Contract documents - Contractor's obligations - General obligations - Materials and workmanship - Commencement time and delays - Liquidated damages for delay - Certificate of Substantial Completion - Outstanding work and defects - Alterations additions and omissions - Procedure for additional payment - Property in materials and Contractor's Equipment - Provisional Sums and Prime Cost Items - Certificates and payment - Remedies and powers - Avoidance and settlement of disputes - Notice of Dispute and amicable dispute resolution - Adjudication - Arbitration - Appointments - The applicable law - Notices - Tax matters - The Construction (Design and Management) Regulations 1994 - Special Conditions - Form of Tender - Appendix to Form of Tender - Form of Agreement - ICE Form of Default Bond