recent advances in medicinal chemistry

Recent Advances In Medicinal Chemistry
Author: Atta-ur-Rahman
Publisher: Elsevier
Release Date: 2015-06-16
Pages: 486
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. Edited and written by leading experts in medicinal chemistry research Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Advances In Medicinal Chemistry Research
Author: Edeildo Ferreira Da Silva, Jr.
Publisher:
Release Date: 2019-10-15
Pages: 366
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features â¢Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. â¢Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. â¢Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. â¢Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.

Recent Advances In Medicinal Chemistry
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2015-12-01
Pages: 200
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The series presents highly cited contributions first published in the impact factor journal Mini-Reviews in Medicinal Chemistry. Contributors to this volume have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in medicinal chemistry. Selected chapters in this volume include: - A brief review of polyphenols as phytotherapeutic agents - Flavonoids in foods and biological samples - Cannabinoid use in treating Parkinson’s Disease symptoms … And much more.

Advances In Metallodrugs
Author: Shahid Ul-Islam
Publisher: John Wiley & Sons
Release Date: 2020-07-08
Pages: 432
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Progress In Medicinal Chemistry
Author:
Publisher: Elsevier
Release Date: 2000-02-29
Pages: 215
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume reviews recent advances in five important areas of medicinal chemistry which will be of interest both to chemists and to scientists of other disciplines engaged in medicines research and development. Included are accounts of successful drug discovery programmes, disease targets of unmet medical need, and recent progress in new technologies which are considered by many to hold the key to future developments in medicinal chemistry.The style and organisation of chapters follow a similar pattern to previous volumes but references, where appropriate, now include website addresses of the World Wide Web.

Advances In Medicinal Chemistry
Author: A.B. Reitz
Publisher: Elsevier
Release Date: 1999-12-27
Pages: 200
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

Advances In Medicinal Chemistry
Author: B.E. Maryanoff
Publisher: Elsevier
Release Date: 1999-04-01
Pages: 321
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Recent Advances In Medicinal  Aromatic  And Spice Crops
Author: Syama Prasad Raychaudhuri
Publisher:
Release Date: 1991
Pages: 577
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances In Medicinal Chemistry
Author:
Publisher:
Release Date: 1995
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances In Anticancer Agents In Medicinal Chemistry
Author: Michelle Prudhomme
Publisher: Bentham Science Publishers
Release Date: 2013-06-14
Pages: 485
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.

Recent Advances In Plant Based  Traditional  And Natural Medicines
Author: Subramayam Vemulpad
Publisher: CRC Press
Release Date: 2014-02-24
Pages: 398
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The purpose of this book is to discuss several medicinal plants to find wider application in the domain of medicinal, clinical, and pharmaceutical treatment. Recent Advances in Plant-Based, Traditional, and Natural Medicines serves as a useful source of ideas and an inspiration for further cell and molecular biology research toward developing drugs and treatments from these traditional and plant-based remedies. The book covers a variety of topics and: • Considers the current state of research of traditional and plant-based medicines • Covers the current status of ethnomedicine and medicinal plant discovery • Presents the clinical applications of traditional and plant-based medicines

Herbs  Spices  And Medicinal Plants
Author: Lyle E. Craker
Publisher: Psychology Press
Release Date: 1992
Pages: 359
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

As in previous volumes, readers will find a multidisciplinary forum for communicating knowledge related to the botany, horticulture, and pharmacology of herbs, spices, and medicinal plants. While magical and mystical powers have been associated with these plants through the ages, continued investigations in such areas as production, nomenclature, uses, chemical constitution, and dynamics help elucidate the affiliated chemical and physical processes that contribute to their unique flavor, fragrance, pharmacological, and other bioactive properties. This collection of articles examines the potential of natural products as pesticides, the richness of the Chinese Pharmacopeia, the similarities of Eastern Asian and Eastern North American medicinal plants, the use of borage as a source of gamma linolenic acid, and the botanical nomenclature of medicinal plants.

Medicinal Chemistry   III
Author: P. Pratesi
Publisher: Elsevier
Release Date: 2013-10-22
Pages: 176
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Medicinal Chemistry–III provides information pertinent to the fundamental aspects of medicinal chemistry. This book discusses the mechanism of action of drugs at the molecular level. Organized into eight chapters, this book begins with an overview of the systems for protein biosynthesis that are classified according to their mechanism and the selective action of drugs on their reactions. This text then examines the key structure in the biosynthesis of the peptidoglycans of bacterial cell walls. Other chapters consider the enzymes that transcribe DNA synthesizing RNA, which have structural differences in eukaryotic and prokaryotic cells. This book discusses as well the concepts for drug screening as they have been emerged from neurochemical research. The final chapter deals with the significance of molecular orbital theory in the hands of the biologist or chemists, which lies in its ability to derive information regarding the properties of molecules. This book is a valuable resource for organic, physical, and biological chemists.

Ion Channel Drug Discovery
Author: Brian Cox
Publisher: Royal Society of Chemistry
Release Date: 2014-09-24
Pages: 384
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.

The Practice Of Medicinal Chemistry
Author: Camille Georges Wermuth
Publisher: Elsevier
Release Date: 2015-07-01
Pages: 902
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Advances In Bioactivation Research
Author: Adnan Elfarra
Publisher: Springer Science & Business Media
Release Date: 2009-10-08
Pages: 503
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. It also provides examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.

Medicinal Plants And Fungi  Recent Advances In Research And Development
Author: Dinesh Chandra Agrawal
Publisher: Springer
Release Date: 2017-11-03
Pages: 547
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi.

Recent Advances In Cannabinoid Research
Author: Willard James Costain
Publisher: BoD – Books on Demand
Release Date: 2019-05-10
Pages: 230
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Scientific interest in cannabinoid research is currently experiencing a significant increase because of changing attitudes toward Cannabis and the evolving awareness of its pharmaceutical benefits. Coincidently, numerous jurisdictions are moving toward legalizing Cannabis and Cannabis-derived products, which reflects a larger global movement to understand Cannabis and its bioactive chemicals for their potential biomedical uses, harms, and economic value. Research activities are surging to fill important knowledge gaps in the field of cannabinoids as they continue to be identified. The purpose of this book is to summarize some leading areas of research in the cannabinoid field where knowledge gaps are actively being addressed. The research described herein spans basic biological and clinical research.

Molecular Biology In Medicinal Chemistry
Author: Theodor Dingermann
Publisher: John Wiley & Sons
Release Date: 2006-03-06
Pages: 435
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Handbook Of Research On Medicinal Chemistry
Author: Debarshi Kar Mahapatra
Publisher: Taylor & Francis
Release Date: 2017-11-20
Pages: 626
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.