principles of translational science in medicine

Principles Of Translational Science In Medicine
Author: Martin Wehling
Publisher: Academic Press
Release Date: 2015-04-02
Pages: 364
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Clinical And Translational Science
Author: David Robertson
Publisher: Academic Press
Release Date: 2016-11-25
Pages: 808
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Handbook Of Translational Medicine
Author: Josep M. Llovet
Publisher: Edicions Universitat Barcelona
Release Date: 2016-10-05
Pages: 244
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This handbook aims to capture the basic concepts of translational medicine, understood as a branch of the biomedical field that translates discoveries into the clinical setting. This discipline is currently closing the gap between basic science and clinical research. The book is intended to be straightforward, easy-to-read, intelligible and practical. It describes the basic principles of translational medicine, including major advances in genomics, new technologies, the processing of big data and biobanks. Regarding the biological foundations of translational medicine, we address concepts related to the molecular basis of cancer, inflammation, angiogenesis, stem cells and experimental models. More specifically on translational medicine, we present discoveries and breakthroughs in oncology, neuroscience, metabolic and systemic diseases, and public health. Finally, we have specific sections focused on clinical trials and biomarkers in the genomic era, advances in imaging techniques and entrepreneurship and innovation. Our purpose is to offer a manageable text to guide graduate and post-graduate students, professionals and researchers in biomedicine through the major technologies and advances that have occurred in the translational field. It is also intended to aid residents, fellows and physician-scientists working in hospitals and academic institutions.

Principles And Practice Of Clinical Research
Author: John I. Gallin
Publisher: Academic Press
Release Date: 2012
Pages: 780
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This expanded third edition provides an introduction to the conduct of clinical research as well as more comprehensive and expansive content about the infrastructure necessary for a successful clinical research organization or enterprise. With authors who are experts in clinical research in both the public and private sectors, this publication provides essential information to clinical investigators who wish to develop and conduct well designed patient-based research protocols that comply with rigorous study design, ethical, and regulatory requirements.

Nanoparticles In Translational Science And Medicine
Author:
Publisher: Academic Press
Release Date: 2011-11-14
Pages: 648
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume explores some of the most exciting recent advances in basic research on nanoparticles in translational science and medicine and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Principles And Practice Of Sleep Medicine E Book
Author: Meir H. Kryger
Publisher: Elsevier Health Sciences
Release Date: 2010-11-01
Pages: 1766
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC, Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. Updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. A greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. And, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. Whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! Make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders.

Principles Of Research Methodology
Author: Phyllis G. Supino
Publisher: Springer Science & Business Media
Release Date: 2012-06-22
Pages: 276
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Translational Medicine
Author: Dennis Cosmatos
Publisher: CRC Press
Release Date: 2008-12-17
Pages: 224
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies that lead to regulatory approval of drug release to patients. Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research. Documents Alternative Research Approaches for Faster and More Accurate Data Judgment Calls Elaborating on how to introduce TM into clinical studies, this authoritative work presents a keen approach to building, executing, and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts. This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists, research executives, clinicians, and biostatisticians looking to expedite successful implementation of this important process.

Principles Of Molecular Oncology
Author: Miguel H. Bronchud
Publisher: Springer Science & Business Media
Release Date: 2008-03-16
Pages: 420
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Drawing on years of significant advances and developments, the editors of this third edition have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules.

Pharmacology
Author: Miles Hacker
Publisher: Academic Press
Release Date: 2009-06-19
Pages: 608
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Translational Medicine
Author: James Mittra
Publisher: CRC Press
Release Date: 2016-04-19
Pages: 294
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Principles Of Perinatal And Pediatric HIV AIDS
Author: Lala Mamatha M
Publisher: Wife Goes On
Release Date: 2011-10
Pages: 627
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book is a comprehensive, reliable, up-to-date reference focused on evidence-based, practical information that is required not only to prevent transmission of HIV to children, but also provide holistic care for the infected child. Discusses extensively all the major issues and provides a holistic approach on prevention, care and management of children infected/affected with HIV/AIDS. This book focuses on evidence-based practical information and recent advances in the field and emphasizes on prevention with special reference to mother-to-child transmission of HIV/AIDS. Chapters contributed by the Who’s Who in the field from across the world. This book is useful for hospitals, institutions, governmental and non-governmental organizations involved in caring for children and all practicing physicians, clinicians, pediatricians, obstetricians, family doctors and postgraduate students.

Davidson S Principles And Practice Of Medicine E Book
Author: Brian R. Walker
Publisher: Elsevier Health Sciences
Release Date: 2013-12-06
Pages: 1392
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

More than two million medical students, doctors and other health professionals from around the globe have owned a copy of Davidson’s Principles and Practice of Medicine since it was first published. Today’s readers rely on this beautifully illustrated text to provide up-to-date detail of contemporary medical practice, presented in a style that is concise and yet easy to read. Davidson’s provides the factual knowledge required to practise medicine, explaining it in the context of underlying principles, basic science and research evidence, and shows how to apply this knowledge to the management of patients who present with problems rather than specific diseases. The book has won numerous prizes including being highly commended in the British Medical Association book awards. Davidson’s global perspective is enhanced by the input of an international team of authors and a distinguished International Advisory Board from 17 countries. Building on the foundations laid down by its original editor, Davidson’s remains one of the world’s leading and most respected textbooks of medicine. The underlying principles of medicine are described concisely in the first part of the book, and the detailed practice of medicine within each sub-specialty is described in later system-based chapters. Most chapters begin with a two-page overview of the important elements of the clinical examination, including a manikin to illustrate the key steps in the examination of the relevant system. A practical, problem-based clinical approach is described in the ‘Presenting Problems’ sections, to complement the detailed descriptions of each disease. The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images. 1350 text boxes present information in a way suitable for revision, including 150 clinical evidence boxes summarising the results of systematic reviews and randomised controlled trials and 65 ’In Old Age’ boxes highlighting important aspects of medical practice in the older population. A combined index and glossary of medical acronyms contains over 10 000 subject entries. The contents can also be searched comprehensively as part of the online access to the whole book on the StudentConsult platform. Access over 500 self-testing questions with answers linked to the book’s content for further reading. The text uses both SI and non-SI units to make it suitable for readers throughout the globe. A new chapter specifically on Stroke Disease recognises the emergence of Stroke Medicine as a distinct clinical and academic discipline. A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. New ‘In Adolescence’ boxes recognise the fact that many chronic disorders begin in childhood and become the responsibility of physicians practising adult medicine. These boxes acknowledge the overlap ‘transitional’ phase and highlight the key points of importance when looking after young people. The regular introduction of new authors and editors maintains the freshness of each new edition. On this occasion Dr Ian Penman has joined the editorial team and 18 new authors bring new experience and ideas to the content and presentation of the textbook. An expanded International Advisory Board of 38 members includes new members from several different countries.

Principles And Practice Of Hospital Medicine
Author: Sylvia McKean
Publisher: McGraw Hill Professional
Release Date: 2012
Pages: 2310
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Includes case studies.

Challenges And Opportunities In Using Residual Newborn Screening Samples For Translational Research
Author: Institute of Medicine
Publisher: National Academies Press
Release Date: 2010-12-23
Pages: 84
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Newborn screening samples are used to test more than 4 million infants each year for life-threatening diseases that are treatable if found at birth. These specimens also represent a potentially invaluable resource for public health and biomedical research. The IOM held a workshop to examine issues surrounding the use of residual specimens for translational research.

Pharmacotherapy Principles And Practice Study Guide
Author: Michael D. Katz
Publisher: McGraw Hill Professional
Release Date: 2010-12-17
Pages: 480
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A case-based companion study guide to Pharmacotherapy Principles and Practice, 2e – learn how to apply your knowledge to actual patient situations Pharmacotherapy Principles and Practice Study Guide uses 98 cases to help you learn how to apply pharmacotherapeutic concepts to specific patient situations. Each case is presented in a consistent manner, similar to what you would see in a clinical setting and focuses on one primary topic or problem. Patients discussed in these cases will have drug therapy problems requiring identification and management. For each case, you will be asked to develop a Patient Database, Drug Therapy Problem Worksheet, and Pharmacotherapy Care Plan using the forms provided. These forms are adapted from those originally developed by the American Society of Health System Pharmacists Clinical Skills program. Each case includes: Learning Objectives Patient Presentation Targeted Questions followed by a hint that refers you to pages in Pharmacotherapy Principles and Practice, 2e where you can find the information to answer the question Follow-up Global Perspective which highlights an issue related to the case that is important to countries outside of North America or involve different ethnic groups or races Case Summary

Pharmacotherapy Principles And Practice Study Guide 3 E
Author: Michael D. Katz
Publisher: McGraw Hill Professional
Release Date: 2013-06-22
Pages: 480
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

More than 100 cases teach how you how to apply pharmacotherapeutic concepts to real-world clinical situations Pharmacotherapy Principles and Practice Study Guide, Third Edition, includes more than 100 patient cases that correspond to chapters in the third edition of Pharmacotherapy Principles and Practice. These cases are presented in realistic fashion, using terms and abbreviations that would normally be found in a patient's medical record. Patients in these cases have drug therapy problems requiring identification and management. For each case, you will be asked to develop a Patient Database, Drug Therapy Problem Worksheet, and Pharmacotherapy Care Plan, using the forms provided. With Pharmacotherapy Principles and Practice Study Guide you will learn how to navigate through the process of applying your knowledge of pharmacotherapy to specific patient cases by organizing patient data to logically assess a patient's medication issues and formulate a sound pharmacotherapy care plan. EACH CASE INCLUDES: Learning Objectives Patient Presentation Targeted Questions followed by hints that refer you to pages in Pharmacotherapy Principles and Practice, Third Edition, where you can find the information necessary to answer the question Follow-Up Global Perspective which highlights an issue related to the case that is important to countries outside of North America or involves selected ethic groups or races Case Summary Student Workup where you are asked to review the patient case for missing information and to complete the various patient forms

Integrating East Asian Medicine Into Contemporary Healthcare E Book
Author: Volker Scheid
Publisher: Elsevier Health Sciences
Release Date: 2011-10-24
Pages: 256
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Traditional East Asian healthcare systems have moved rapidly from the fringes of healthcare systems in the West towards the centre over the past 50 years. This change of status for traditional medicines presents their practitioners with both opportunities and challenges as the focus shifts from one of opposition towards one of integration into biomedically dominated healthcare systems. Integrating East Asian Medicine into Contemporary Healthcare examines the opportunities and challenges of integrating East Asian medicine into Western healthcare systems from an interdisciplinary perspective. Volker Scheid and Hugh MacPherson bring together contributions from acknowledged experts from a number of different disciplines - including clinical researchers, Chinese Medicine practitioners, historians, medical anthropologists, experts in the social studies of science, technology and medicine - to examine and debate the impact of the evidence-based medicine movement on the ongoing modernization of East Asian medicines. The book considers the following questions: •What are the values, goals and ethics implicit within traditional East Asian medical practices? • What claims to effectiveness and safety are made by East Asian medical practices? •What is at stake in subjecting these medical practices to biomedical models of evaluation? • What constitutes best practice? How is it to be defined and measured? • What are the ideologies and politics behind the process of integration of East Asian medical practices into modern health care systems? • What can we learn from a variety of models of integration into contemporary healthcare?

Clinical Research In Oral Health
Author: William V. Giannobile
Publisher: John Wiley & Sons
Release Date: 2009-12-09
Pages: 344
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Clinical Research in Oral Health surveys the essentials of clinical research in oral health, anchoring these principles within the specific context of the oral health arena. Addressing research questions exclusively applicable to dentistry and oral health, the book thoroughly illustrates the principles and practice of oral health clinical research. Clinical Research in Oral Health also clarifies the framework of regulatory issues and presents emerging concepts in clinical translation, relating the research principles to clinical improvement.

Translational Regenerative Medicine
Author: Anthony Atala
Publisher: Academic Press
Release Date: 2014-12-01
Pages: 606
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine