predictive modeling of pharmaceutical unit operations

Predictive Modeling Of Pharmaceutical Unit Operations
Author: Preetanshu Pandey
Publisher: Woodhead Publishing
Release Date: 2016-09-26
Pages: 464
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points

Chemical Engineering In The Pharmaceutical Industry
Author: Mary T. am Ende
Publisher: John Wiley & Sons
Release Date: 2019-04-01
Pages: 688
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Continuous Manufacturing Of Pharmaceuticals
Author: Peter Kleinebudde
Publisher: John Wiley & Sons
Release Date: 2017-09-05
Pages: 620
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

10.7.3 State of Control

Predictive Toxicology
Author: Friedlieb Pfannkuch
Publisher: John Wiley & Sons
Release Date: 2014-10-15
Pages: 432
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.

Pharmaceutical Operations Management
Author: Pankaj Mohan
Publisher: McGraw Hill Professional
Release Date: 2006-03-16
Pages: 364
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book brings together a winning team of international operations experts to set the framework for building a world-class manufacturing organization. Pharmaceutical Operations Management focuses on key concepts such as: Policy Execution, Risk Management, Supply chain modeling, Advance process control and Six Sigma for the pharmaceutical industry: critical techniques which will offset cost, increase efficiency and turn any manufacture into financial winner.

The Chemical Engineer
Author:
Publisher:
Release Date: 2007
Pages:
ISBN:
Available Language: English, Spanish, And French
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21st European Symposium On Computer Aided Process Engineering
Author:
Publisher: Elsevier
Release Date: 2011-06-10
Pages: 2082
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of computer aided process engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges," described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies."

Proceedings Of The 8th International Conference On Foundations Of Computer Aided Process Design
Author:
Publisher: Elsevier
Release Date: 2014-07-14
Pages: 840
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume collects together the presentations at the Eighth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2014, an event that brings together researchers, educators, and practitioners to identify new challenges and opportunities for process and product design. The chemical industry is currently entering a new phase of rapid evolution. The availability of low-cost feedstocks from natural gas is causing renewed investment in basic chemicals in the OECD, while societal pressures for sustainability and energy security continue to be key drivers in technology development and product selection. This dynamic environment creates opportunities to launch new products and processes and to demonstrate new methodologies for innovation, synthesis and design. FOCAPD-2014 fosters constructive interaction among thought leaders from academia, industry, and government and provides a showcase for the latest research in product and process design. Focuses exclusively on the fundamentals and applications of computer-aided design for the process industries. Provides a fully archival and indexed record of the FOCAPD14 conference Aligns the FOCAPD series with the ESCAPE and PSE series

Continuous Processing In Pharmaceutical Manufacturing
Author: Ganapathy Subramanian
Publisher: John Wiley & Sons
Release Date: 2014-12-03
Pages: 528
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.

Industrial Management
Author:
Publisher:
Release Date: 1987
Pages:
ISBN:
Available Language: English, Spanish, And French
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Chemical Engineering Progress
Author:
Publisher:
Release Date: 2006
Pages:
ISBN:
Available Language: English, Spanish, And French
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Vehicle  Mechatronics And Information Technologies
Author: X.D. Yu
Publisher: Trans Tech Publications Ltd
Release Date: 2013-08-30
Pages: 5174
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Collection of selected, peer reviewed papers from the 2013 International Conference on Vehicle & Mechanical Engineering and Information Technology (VMEIT 2013), August 17-18, 2013, Zhengzhou, Henan, China. The 1094 papers are grouped as follows: Chapter 1: Design and Researches in Area of Vehicle and General Mechanical Engineering; Chapter 2: Mechatronics, Automation and Control; Chapter 3: Measurement and Instrumentation, Monitoring and Detection Technologies, Fault Diagnosis; Chapter 4: Computation Methods and Algorithms for Modeling, Simulation and Optimization, Data Mining and Data Processing; Chapter 5: Information Technologies, WEB and Networks Engineering, Information Security, Software Application and Development; Chapter 6: Power and Electric Systems, Electronics and Microelectronics, Embedded and Integrated Systems; Chapter 7: Communication, Signal and Image Processing, Data Acquisition, Identification and Recognition Technologies; Chapter 8: Information Technologies in Urban and Civil Engineering, Medicine and Biotechnology; Chapter 9: Material Science and Manufacturing Technology; Chapter 10: Information Technology in Management Engineering, Logistics, Economics, Finance, Assessment; Chapter 11: Related Themes.

Process Control
Author: B. Wayne Bequette
Publisher: Prentice Hall Professional
Release Date: 2003
Pages: 769
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Process Control: Modeling, Design, and Simulation is the first complete introduction to process control that fully integrates software tools-helping you master critical techniques hands-on, using MATLAB-based computer simulations. Author B. Wayne Bequette includes process control diagrams, dynamic modeling, feedback control, frequency response analysis techniques, control loop tuning, and start-to-finish chemical process control case studies.

Process Systems Engineering 2003
Author: Bingzhen Chen
Publisher: Elsevier
Release Date: 2003-06-06
Pages: 1519
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Contains proceedings from the 8th International Symposium on Process Systems Engineering (PSE), which brought together the global community of process systems engineering researchers and practitioners involved in the creation and application of computing based methodologies for planning, design, operation, control, and maintenance of chemical processes. Contains proceeding from the 8th International Symposium on Process Systems Engineering Conference theme for PSE 2003 is 'supporting business decision making'

11th International Symposium On Process Systems Engineering   PSE2012
Author:
Publisher: Elsevier
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Frontiers Of Chemical Engineering  Metallurgical Engineering And Materials II
Author: Jimmy Chih Ming Kao
Publisher: Trans Tech Publications Ltd
Release Date: 2013-09-10
Pages: 526
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Volume is indexed by Thomson Reuters CPCI-S (WoS). Collection of selected, peer reviewed papers from the 2013 Second International Conference on Chemical Engineering, Metallurgical Engineering and Metallic Materials (CMMM 2013), August 3-4, 2013, Dali, China. The 106 papers are grouped as follows: Chapter 1: Chemical Engineering, Bio, Environmental Chemistry Engineering and Technologies; Chapter 2: Materials Engineering; Chapter 3: Mining and Metallurgical Engineering; Chapter 4: Manufacturing and Industry Technologies, Mechatronics Engineering.

InTech
Author:
Publisher:
Release Date: 1989
Pages:
ISBN:
Available Language: English, Spanish, And French
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Management Science Operations Research
Author: Elwood Spencer Buffa
Publisher: John Wiley & Sons
Release Date: 1977
Pages: 725
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

CEP Software Directory
Author:
Publisher:
Release Date: 1995
Pages:
ISBN:
Available Language: English, Spanish, And French
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Plant Wide Process Control
Author: Kelvin T. Erickson
Publisher: John Wiley & Sons
Release Date: 1999-04-29
Pages: 547
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The complete control system engineering solution for continuous and batch manufacturing plants. This book presents a complete methodology of control system design for continuous and batch manufacturing in such diverse areas as pulp and paper, petrochemical, chemical, food, pharmaceutical, and biochemical production. Geared to practicing engineers faced with designing increasingly more sophisticated control systems in response to present-day economic and regulatory pressures, Plantwide Process Control focuses on the engineering portion of a plant automation improvement project. It features a full control design information package (Control Requirements Definition or CRD), and guides readers through all steps of the automation process-from the initial concept to design, simulation, testing, implementation, and operation. This unique and practical resource: * Integrates continuous, batch, and discrete control techniques. * Shows how to use the methodology with any automation project-existing or new, simple or complex, large or small. * Relates recent ISO and ISA standards to the discipline of control engineering. * Illustrates the methodology with a pulp-and-paper mill case study. * Incorporates numerous other examples, from single-loop controllers to multivariable controllers.