personalized psychiatry

Personalized Psychiatry
Author: Bernhard Baune
Publisher: Academic Press
Release Date: 2019-10-16
Pages: 604
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Personalized Psychiatry
Author: Ives Cavalcante Passos
Publisher: Springer
Release Date: 2019-02-12
Pages: 180
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book integrates the concepts of big data analytics into mental health practice and research. Mental disorders represent a public health challenge of staggering proportions. According to the most recent Global Burden of Disease study, psychiatric disorders constitute the leading cause of years lost to disability. The high morbidity and mortality related to these conditions are proportional to the potential for overall health gains if mental disorders can be more effectively diagnosed and treated. In order to fill these gaps, analysis in science, industry, and government seeks to use big data for a variety of problems, including clinical outcomes and diagnosis in psychiatry. Multiple mental healthcare providers and research laboratories are increasingly using large data sets to fulfill their mission. Briefly, big data is characterized by high volume, high velocity, variety and veracity of information, and to be useful it must be analyzed, interpreted, and acted upon. As such, focus has to shift to new analytical tools from the field of machine learning that will be critical for anyone practicing medicine, psychiatry and behavioral sciences in the 21st century. Big data analytics is gaining traction in psychiatric research, being used to provide predictive models for both clinical practice and public health systems. As compared with traditional statistical methods that provide primarily average group-level results, big data analytics allows predictions and stratification of clinical outcomes at an individual subject level. Personalized Psychiatry – Big Data Analytics in Mental Health provides a unique opportunity to showcase innovative solutions tackling complex problems in mental health using big data and machine learning. It represents an interesting platform to work with key opinion leaders to document current achievements, introduce new concepts as well as project the future role of big data and machine learning in mental health.

Extraordinary Science And Psychiatry
Author: Jeffrey Poland
Publisher: MIT Press
Release Date: 2017-01-13
Pages: 344
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Leading scholars offer perspectives from the philosophy of science on the crisis in psychiatric research that exploded after the publication of DSM-5.

Textbook Of Personalized Medicine
Author: Kewal K. Jain
Publisher: Humana Press
Release Date: 2015-03-17
Pages: 732
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Advancing Healthcare Through Personalized Medicine
Author: Priya Hays
Publisher: CRC Press
Release Date: 2017-02-24
Pages: 167
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This innovative book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it will help mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to underlying concepts at the heart of personalized medicine - pharmacogenomics, targeted therapies and individualized diagnosis and treatment - and shows how, with the advent of genomic technologies, clinicians will have the capability to predict and diagnose disease more efficiently. Advocating a patient-centred approach at the heart of care, this introduction to personalized medicine, the science behind it, its economic effects, its effects upon patients and its overall implications for society will be invaluable to clinicians, to healthcare providers and to patients.

Integrative Neuroscience And Personalized Medicine
Author: Evian Gordon
Publisher: Oxford University Press
Release Date: 2010-12-21
Pages: 323
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book takes an in depth and hard look at the current status and future direction of treatment predictive markers in Personalized Medicine for the brain from the perspectives of the researchers on the cutting edge and those involved in healthcare implementation. The contents provide a comprehensive text suitable as both a pithy introduction to and a clear summary of the "science to solutions" continuum in this developing field of Personalized Medicine and Integrative Neuroscience. The science includes both measures of genes using whole genome approaches and SNIPS as well as BRAINmarkers of direct brain function such as brain imaging, biophysical changes and objective cognitive and behavioral measurements. Personalized Medicine for Brain Disorders will soon be a reality using the comprehensive quantitative and standardized approaches to genomics, BRAINmarkers and cognitive function. Each chapter provides a review of recent relevant literature; show the solutions achieved through integrative neuroscience and applications in patient care thus providing a practical guide to the reader. The timeliness of this book's content is propitious providing bottom line information to educate practicing clinicians, health care workers and researchers, and also a pathway for undergraduate and graduates interested in further their understanding of and involvement in tailored personal solutions.

Pharmacogenomics In Psychiatry
Author: Matthias Schwab
Publisher: Karger Medical and Scientific Publishers
Release Date: 2010-01-01
Pages: 139
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research. Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Exam Prep For  Personalized Psychiatry
Author:
Publisher:
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

MOVING TOWARDS PERSONALIZED MEDICINE IN PSYCHIATRY  A VALUE OF GENOTYPING IN ASSESSING OF RISKS AND BENEFITS IN PATIENTS RECEIVING SSRIu2019S AND CARDIOVASCULAR MEDICATION
Author: Linda de Jonge
Publisher:
Release Date: 2017
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Introduction: A high prevalence of poor metabolizers (6-10%) in western population is a potential source of drug-drug interactions. To date, the human pharmacokinetic data on SSRiu2019s and cardioprotective drugs are inconclusive because of the wide interpersonal variation in outcomes, a limitation which can be eliminated by a personalized approach through genotyping to identify patients at risk (slow metabolizers). Objectives & Methods: First, we performed a meta-analysis to assess the effect of SSRIu2019s on percentage change in AUC of statins in general population. Secondly, we reviewed the neuropsychiatric effects of antihypertensive drugs when co-administrated with SSRIu2019s. Finally, we speculated on the value of genotyping as a potential tool to identify patients at risk. Results: Fluvoxamine increased the mean substrate AUC 0-[infinity] by 112.47% (CI: 21.08; 203.86). The AUC 0-[infinity] levels of CYP3A4 substrates were marginally increased by 11.1% in citalopram treated subjects (CI: -20.63; 42.86), by 10.8% in fluoxetine treated group (CI: -25.53; 47.16), by 8.18% in those who received paroxetine (CI: -3.49; 19.86) and by -3.3% in venlafaxine treated group (CI: -5.85; -0.75). Based on literature search, clinically important links may exist between SSRIu2019s with propranolol, metoprolol and amlodipine. Conclusions: Citalopram, fluoxetine, paroxetine and venlafaxine are almost certain to be safe with all statins. Fluvoxamine inhibits CYP3A4 metabolic pathway and is potentially unsafe in cotherapy with atorvastatin, simvastatin and lovastatin. Co-administration of lipophilicu03b2-blokkers are thought to be associated with higher rates of neuropsychiatric consequences. We advocate for genotyping in patients experiencing adverse events and in those receiving polypharmacy.

Personalized Nutrition
Author: Artemis P. Simopoulos
Publisher: Karger Medical and Scientific Publishers
Release Date: 2010
Pages: 180
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Awareness of the influence of our genetic variation to dietary response (nutrigenetics) and how nutrients may affect gene expression (nutrigenomics) is prompting a revolution in the field of nutrition. Nutrigenetics/Nutrigenomics provide powerful approaches to unravel the complex relationships among nutritional molecules, genetic variants and the biological system. This publication contains selected papers from the '3rd Congress of the International Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions address frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics as well as non-coding RNAs and posttranslational gene regulations in various diseases and conditions. In addition to scientific studies, the challenges and opportunities facing governments, academia and the industry are included. Everyone interested in the future of personalized medicine and nutrition or agriculture, as well as researchers in academia, government and industry will find this publication of the utmost interest for their work.

Electrophysiology And Psychophysiology In Psychiatry And Psychopharmacology
Author: Veena Kumari
Publisher: Springer
Release Date: 2014-11-08
Pages: 390
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Psychophysiology is an ever expanding field. The application of psychophysiological investigations to psychiatric disorders is likewise expanding and has in fact shed much light on some of the neural processes contributing to the development of psychiatric symptoms and/or their amelioration following treatment. In the first part of this volume, we have selected a number of conditions where psychophysiological investigations have recently provided some insight into the pathophysiology of a particular manifestation (e.g., dissociation) or a disorder. Although this volume has a main focus on electrophysiological investigative modalities where neuroimaging was complimentary this added insight was included. The second part of the volume focuses on novel uses of psychophysiological measures, combining it with neuropsychology and imaging where possible, in the context of neuropsychiatric research and describes advanced analytical tools. Both basic and clinical investigators in this field should find the reviews and interpretations provided clear and informative. Clinicians will find this volume easy to assimilate. While direct clinical applications may be down the road, the insights provided should help the practicing clinicians to have firmer understanding of the complexity of the disorder they manage in everyday practice.

Geriatric Psychiatry  An Issue Of Psychiatric Clinics   E Book
Author: George S. Alexopoulos
Publisher: Elsevier Health Sciences
Release Date: 2011-06-06
Pages: 256
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This issue covers a broad selection of topics critical to psychiatrist and any physician who treats older patients. Topics include: Epidemiology, clinical evaluation, and treatment of dementing disorders, late-life psychosis; suicide in late life; depression in primary care; structural neuroimaging of geriatric depression; gene-environment interactions in geriatric depression; treatment of geriatric depression; etiological Theories of Late-Life depression; geriatric bipolar disorder; psychotherapies in geriatric depression; home-based care of the elderly with mental disorders; functional neuroimaging in geriatric depression; models of treatment engagement of geriatric persons with mental disorders; and mental health service delivery to the elderly.

Psychiatry
Author: Allan Tasman
Publisher: John Wiley & Sons
Release Date: 2015-02-05
Pages: 2768
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

Breakthrough Depression Solution   A Personalized Model For Relief From Depression
Author: James Greenblatt
Publisher:
Release Date: 2016
Pages: 304
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The ideas as to what causes depression are not based on strong science, and our treatments are not working nearly as well as they should. Psychiatry is in crisis. The usual treatment mode (typically based solely on a subjective psychiatric examination and construction of a symptom list) often leads to psychiatrists blindly searching for a medication that might work. Other factors such as nutrition, toxins, hormones, allergies, biochemical risks, and medical disorders are typically ignored. No amount of changing this approach will work because the basic underlying concepts are wrong. We need an entirely new way of looking at patients. We must stop treating them according to lists of subjective symptoms, and we must stop acting as if one person were the same as the next. Instead, we must start seeing patients as individuals and then diagnose and treat their disorders accordingly. James Greenblatt, MD, a pioneer in the field of integrative medicine, has been successfully treating patients with nutritional and metabolic therapies for more than twenty-five years. In this book, he provides a personalized model of integrative medicine for mental health that can result in relief from depression and a renewed sense of emotional health. This groundbreaking book offers hope and treatment models that are proven, simple, safe, and effective.

Stress In Health And Disease  An Issue Of Psychiatric Clinics Of North America
Author: Daniel L. Kirsch
Publisher: Elsevier Health Sciences
Release Date: 2014-12-27
Pages: 281
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Stress in the DSM is referred to only in the sense of post traumatic stress disorder (PTSD). However, some research studies estimate up to two thirds of illnesses seen by general practitioners are ‘stress related’–GI problems, sleep disturbance, mental concentration, headaches, fatigue, shortness of breath, high blood pressure, dermatitis, illnesses from lowered immune system, and vague aches and pains – all can be symptoms and outcomes of the elusive stress factor. This issue of Psychiatric Clinics of North America discusses the scientific medical facets of stress, written by mental health and medical practitioners. It looks at the brain-body connection of stress – what the body does to result in stress and varying results stress has on the body. This fascinating cross-discipline look at stress is intended for psychiatrists, general practitioners, cardiologists, GI specialists, neurologists, sleep medicine specialists, respiratory specialists, and others who diagnose and treat patients with stress suspected as part of the illness equation or with self-reported stress. Topics include: Measurement of stress; Anxiety and stress-how they work together; Relationship between genetics and stress; Role of glia in stress; Sleep and stress; Diet and stress; Supplements and stress; Effect of severe stress on early brain development, attachment, and emotions; Role of stress and fear on the development of psychopathology; Expressions of stress in psychiatric illness; Dermatologic manifestations of stress in normal and psychiatric populations; Humor and the psychological buffers of stress; Stress expression in children and adolescents; Stress in service members; Stress in the geriatric population.

Year Book Of Psychiatry And Applied Mental Health 2012   E Book
Author: John A. Talbott
Publisher: Elsevier Health Sciences
Release Date: 2012-03-05
Pages: 384
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Year Book of Psychiatry and Applied Mental Health brings you abstracts of the articles that reported the year's breakthrough developments in psychiatry and mental health, carefully selected from more than 300 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Annual topics feature the latest information on biological psychiatry, alcohol and substance-related disorders, psychiatry and the law, psychotherapy, and clinical psychiatry.

Comprehensive Medicinal Chemistry II  Volume 1
Author: Peter Kennewell
Publisher: Elsevier Science
Release Date: 2006-11-15
Pages: 881
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume provides and educative and authoriative discussions on the drug discovery and development process. It is divided into ten sections and starts with personal recollections on the history and evolution of the drug discovery process. To illustrate the end result of the drug discovery process, a large chapter reviews the major drug introductions over 1993-2003. Subsequent chapters examine the impact of genomic technologies, new sources of drugs and alternatives to animal testing. The next section reviews the roles of enterprise and pharamaceuticals companies, venture capitalists and academic-industrial relations in the drug discovery process. Social and ethical issues are reviewed in the context of assessing health demands in developed, developing countries and also in relation to smaller scale diseases (orphan drugs). Two chapters then review the bioethical and ethical issues facing the pharmaceutical industry. The volume concludes with reviews on funding and regulartion and how intellectual property rights and patents are protected. With such a wide variety of topics this volume will appeal to both scientists and non-scientists who need to understand how and why the pharmaceutical industry works. * valuable content available from May 2009 as an individual volume * provides a global overview of the drug discovery process

Disaster And Trauma  An Issue Of Child And Adolescent Psychiatric Clinics Of North America
Author: Stephen J Cozza
Publisher: Elsevier Health Sciences
Release Date: 2014-03-30
Pages: 281
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An overview of childhood traumatic exposures and their impact for health care providers - child and adolescent psychiatrists, general psychiatrists, other pediatric behavioral health providers and primary care clinicians - is presented. Most clinicians are unaware that children in the United States are exposed to trauma frequently, either as a single occurrence, or through repeated events. These exposures result in neurobiological, developmental and clinical sequelae that can undermine children's health and well-being. This issue describes the multiple types of traumatic exposures and their sequelae, methods of screening and assessment, and principles of effective prevention and clinical treatment. The volume highlights areas of particular relevance to children, such as natural disasters, war, domestic violence, school and community violence, sexual victimization, and complex trauma. Each is differentiated as a unique trauma, requiring trauma-informed systems of care to effectively meet the needs of the exposed population. Since traumatic exposure results in added risk to child well-being, the third section of the volume describes strategies for primary prevention (e.g. violence prevention) and risk mitigation (e.g. skill and resilience building strategies), as well as reviews evidence based treatments for trauma-induced clinical disorders.

Textbook Of Biological Psychiatry
Author: Jaak Panksepp
Publisher: Wiley-Liss
Release Date: 2004
Pages: 699
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A Textbook of Biological Psychiatry integrates the basic science concerning brain mechanisms of psychiatric disorders alongside surveys of present standard clinical treatment. Organized in a coherent and easy to follow structure, chapters expand across different levels of analysis, from basic mechanisms to clinical practice. This comprehensive reference provides an integrative treatment of the biochemistry of neurotransmission, behavioral pharmacology, and clinical aspects of psychiatric problems including depression, manic-depression, and mood disorders. Other chapters address the biological mechanisms and treatment of depression, anxiety, panic, obsessive-compulsive disorder, and addictions. The editor concludes with a perspective on the future of the field and prospects for understanding and effectively treating mood and anxiety disorders.

Handbook Of Personalized Medicine
Author: Ioannis S. Vizirianakis
Publisher: CRC Press
Release Date: 2014-02-12
Pages: 1560
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.