personalized immunosuppression in transplantation

Personalized Immunosuppression In Transplantation
Author: Michael Oellerich
Publisher: Elsevier
Release Date: 2015-08-08
Pages: 316
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Personalized Immunosuppression In Transplantation
Author: Michael Oellerich
Publisher: Elsevier
Release Date: 2015-09-17
Pages: 316
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Personalized Immunosuppression In Transplantation
Author: Michael Oellerich
Publisher: Elsevier
Release Date: 2015-09-17
Pages: 316
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Gastrointestinal Transplantation  An Issue Of Gastroenterology Clinics Of North America  E Book
Author: Enrico Benedetti
Publisher: Elsevier Health Sciences
Release Date: 2018-05-16
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Guest Editors have put together a concise monograph on the latest advances in transplantation of the liver, intestine, and pancreas. Expert authors have written comprehensive reviews on the following topics: Living donor liver transplantation: Technical innovations; Liver transplantation for cholangiocarcinoma; Immunological monitoring to personalize immunosuppression after liver transplantation; Status of adult LDLT in US based on A2ALL; Pediatric liver transplantation; Modern treatment of fulminant liver failure; Intestinal failure and rehabilitation; Adult intestinal transplantation; Pediatric intestinal transplantation; Living donor intestinal transplantation; Endoscopic follow-up of intestinal transplant recipients; Multivisceral transplantation; Pancreas transplantation for DM1 and DM2; and Robotic pancreas transplantation. Readers will come away with the clinical information they need to stay current on issues surrounding gastrointestinal transplantations.

Disease Recurrence After Liver Transplantation
Author: Paul J. Thuluvath
Publisher: Springer
Release Date: 2015-11-11
Pages: 269
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

Textbook Of Personalized Medicine
Author: Kewal K. Jain
Publisher: Springer Science & Business Media
Release Date: 2009-08-29
Pages: 430
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

Pediatric Liver Transplantation E Book
Author: Nedim Hadzic
Publisher: Elsevier Health Sciences
Release Date: 2020-11-13
Pages: 512
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications. Provides an in-depth understanding of all aspects of pediatric liver transplantation, ideal for pediatric hepatologists, pediatric transplant surgeons, and others on the pediatric transplant team. Covers all surgical techniques in detail, including split graft, living related, auxiliary, and domino. Discusses pediatric liver transplantation consideration for an increasing number of additional metabolic, hematologic and renal conditions; breakthroughs in grafting and stem cell therapy; and techniques and present role of hepatocyte transplantation. Uses a quick-reference templated format; each chapter includes an overview, pathophysiology, conventional management, controversies, and bulleted summary of key take-aways. Includes state-of-the-art mini-reviews based on updated references and author experience throughout the text. Features a full-color design with numerous algorithms, figures, and radiological and histopathological photos.

Kidney Transplantation
Author: Massimiliano Veroux
Publisher: Bentham Science Publishers
Release Date: 2012-08
Pages: 398
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This e-book is an overview of recent advances in the realm of kidney transplantation. The volume discusses developments in surgical procedures while presenting a perspective on possibilities for kidney transplant research in the future. The e-book is a c

Cardiac Surgery In The Adult  Fourth Edition
Author:
Publisher: McGraw Hill Professional
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Current Topics In Transplantation  An Issue Of Surgical Clinics
Author: A. Osama Gaber
Publisher: Elsevier Health Sciences
Release Date: 2013-11-14
Pages: 217
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An important review on transplantation for the general surgeon! Topics include: kidney transplant, left lobe liver transplants, advances in lung transplantation, stem cell and cellular transplants, pancreatectomy, management of organ failure, transplant immune suppression, antibody mediated rejection, cardiac assist devices, organ perfusion and preservation, weight reduction therapy, organ allocation and distribution, and more!

Brenner And Rector S The Kidney E Book
Author: Maarten W. Taal
Publisher: Elsevier Health Sciences
Release Date: 2011-11-01
Pages: 3064
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.

Cardiac Surgery In The Adult 5 E
Author: Lawrence H. Cohn
Publisher: McGraw Hill Professional
Release Date: 2017-09-08
Pages: 1408
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The most comprehensive and current full-color cardiac surgery resource – updated by leading surgeons In Cardiac Surgery in the Adult, Fifth Edition, the world’s foremost cardiovascular surgeons deliver thorough, up-to-date coverage of operative strategy, decision making, technique, and pre- and post-operative management for treating the adult cardiac patient. Unmatched in both scope and clinical rigor, this classic text contains 63 chapters that highlight every important topic in cardiovascular surgery. Presented in full color, Cardiac Surgery in the Adult takes readers through the optimal treatment of congenital, acquired, infectious, and traumatic diseases of the heart and great vessels. The book opens with a history of cardiac surgery and basic cardiac science, then moves into all types of cardiac surgery, providing both practicing surgeons and residents with insight into the very latest surgical protocols. Cardiac Surgery in the Adult is logically divided into ten sections: • Basics (includes history, anatomy, physiology, pharmacology, computed tomography, risk assessment, simulation, and the fully integrated cardiovascular center) • Perioperative/Intraoperative Care • Ischemic Heart Disease • Aortic Valve Disease • Mitral Valve Disease • Surgery of the Great Vessels • Rhythm Surgery • Other Cardiac Operations (including congenital heart disease, pericardial disease, and cardiac neoplasms) • Transplant and Mechanical Circulatory Support The Fifth Edition has been updated throughout, and includes the latest advances in minimally invasive surgery and simulation.

The Multiple Therapeutic Targets Of A20
Author: Christiane Ferran
Publisher: Springer
Release Date: 2014-09-26
Pages: 188
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.

Chemical Abstracts
Author:
Publisher:
Release Date: 2002
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Metabolic Drug Interactions With Immunosuppressants
Author: Katalin Monostory
Publisher:
Release Date: 2018
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Organ transplantation has become a routine clinical practice for patients with end-stage disease of liver, kidney, heart, or lung. Although improved immunosuppressant therapy substantially contributes to the success of transplantation, clinicians continue to face challenges because of wide interindividual variations in blood concentrations resulting in subtherapeutic or supratherapeutic levels. Many undesired side-effects or therapeutic failure of immunosuppressants as a consequence are the results of differences or changes in drug metabolism. Considering genetic and nongenetic factors, such as co-medication, can refine the immunosuppressant therapy, facilitating personalized treatments to individual recipients. This review provides an up-to-date summary of functional polymorphisms of enzymes involved in the metabolism of immunosuppressants with low molecular weight and of the clinical significance of metabolic drug interactions between immunosuppressive agents and other drugs in therapeutic regimens of transplant recipients.

An Immense New Power To Heal
Author: Lee Gutkind
Publisher: Underland Press
Release Date: 2012-03-23
Pages: 320
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Is personalized medicine—what some scientists call genetic medicine—a pipe dream or a panacea? Francis Collins, current director of the National Institutes of Health and director of the Human Genome Project, considers this new era “the greatest revolution since Leonardo,” while Nobel Laureate Leland Hartwell compares personalized medicine to a train that has not yet left the station—“a very slow train with a very long way to go . . . before we arrive at our destination.” There is no denying that new technology, which has triggered an explosion of scientific information, is ushering in a revolution in medicine—for specialists, general practitioners and the public. Anyone can spit in a cup and, for a small fee, learn about his or her individual genetic make-up. But how useful is this information, really, to us or to our doctors? What’s more, how much do we truly want to know—and have others know—about our possible destiny? There is more than we can imagine at stake. In An Immense New Power to Heal, authors Lee Gutkind and Pagan Kennedy delve into the personal side of personalized medicine and offer the physician’s perspective and the patient’s experience through intimate narratives and case studies. They also offer an intriguing background of the personalized medicine movement including the fascinating personalities of the key scientists involved as well as a glimpse into the in-fighting that accompanies any race for a scientific breakthrough. The result is a highly engaging, lively, and provocative discussion about this revolution in health care, and most importantly, what it really means for patients now and in the future.

ICU Care Of Abdominal Organ Transplant Patients
Author: Ali Al-Khafaji
Publisher: Oxford University Press
Release Date: 2013-04-11
Pages: 274
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Pre- and post-operative care of transplant patients is an aspect of Critical Care Medicine in which most ICU physicians and nurses have received little or no formal training and are left to cope with this complex population with only spotty, incomplete 'on-the-job experience' as a guide. In response to this clinical knowledge gap, this book provides a concise 'at the bedside' resource for clinicians caring for abdominal organ transplant patients before and after surgery.

Cellular Transplantation
Author: Craig Halberstadt
Publisher: Academic Press
Release Date: 2007
Pages: 676
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. This book features: . Detailed description of clinical trials in cell transplantation . Review of current therapeutic approaches . Coverage of the broad range of diseases addressed by cell therapeutics . Discussion of stem cell biology and its role in transplantation About the editors Dwaine Emerich is Vice President of Research and Chief Scientific Officer for LCT BioPharma, having previously held the same position at Sertoli Technologies Inc. He has also held the position of Director of Biological Research at Alkermes Inc. and CytoTherapeutics Inc. His research interests include cell transplantation, drug delivery, nanotechnology and tissue engineering. Craig Halberstadt is the Director of Tissue Engineering at the Carolinas Medical Center in Charlotte, North Carolina. With prior positions at Desmos, Inc. and Advanced Tissue Sciences, his research focuses on cell transplantation, cell/biomaterial interactions, and in vivo reconstruction of new tissues.

Pharmacogenomics And Proteomics
Author: Steven How-Yan Wong
Publisher: AACC Press
Release Date: 2006
Pages: 386
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Reviews the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.

Progress In Systemic Lupus Erythematosus Research
Author: Tomas I. Seward
Publisher: Nova Publishers
Release Date: 2007
Pages: 264
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This new book is devoted to leading-edge research developments in lupus which is a condition of chronic inflammation caused by an autoimmune disease. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, for example, bacteria, and other foreign invaders. One of the mechanisms that the immune system uses to fight infections is the production of antibodies. Patients with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. Because the antibodies and accompanying cells of inflammation can involve tissues anywhere in the body, lupus has the potential to affect a variety of areas of the body. Sometimes lupus can cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).