perinatal stem cells

Perinatal Stem Cells
Author: Anthony Atala
Publisher: Academic Press
Release Date: 2018-06-14
Pages: 418
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Perinatal Stem Cells
Author: Zhong Chao Han
Publisher: Springer
Release Date: 2019-04-06
Pages: 173
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Perinatal Stem Cells
Author: Kyle Cetrulo
Publisher: John Wiley & Sons
Release Date: 2013-02-04
Pages: 320
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Perinatal Stem Cells, 2nd Edition builds on the firstedition to provide an updated tutorial on perinatal stem cells,including stem cells harvested from the amniotic fluid, placenta,maternal blood supply, umbilical cord and Wharton's Jelly. As inthe first edition, coverage includes the underlying biology of eachof the sources of pregnancy related stem cells, cell culture, andpotential therapeutic uses, as well as insights on the impact ofthese stem cells from obstetricians and gynecologists,cardiologists, hematologists, tissue engineers, and cord bloodbankers. Normally discarded as medical waste, perinatal stem cells offera powerful therapeutic tool box alternative to the controversialembryonic stem cells. Since publication of the first edition, aburgeoning commerical industry has developed around various sourcesof perinatal cells, and the second edition now includes an overviewof this growing industry. With contributions from some of the top academic stem celllaboratories in the United States as well as new chapters frominternational stem cell scientists, Perinatal StemCells presents an update onthe cutting-edge research in the field whilemaintaining its signature clinical focus.

Perinatal Stem Cells
Author: Kyle Cetrulo
Publisher: John Wiley & Sons
Release Date: 2013-02-05
Pages: 320
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Perinatal Stem Cells, 2nd Edition builds on the firstedition to provide an updated tutorial on perinatal stem cells,including stem cells harvested from the amniotic fluid, placenta,maternal blood supply, umbilical cord and Wharton's Jelly. As inthe first edition, coverage includes the underlying biology of eachof the sources of pregnancy related stem cells, cell culture, andpotential therapeutic uses, as well as insights on the impact ofthese stem cells from obstetricians and gynecologists,cardiologists, hematologists, tissue engineers, and cord bloodbankers. Normally discarded as medical waste, perinatal stem cells offera powerful therapeutic tool box alternative to the controversialembryonic stem cells. Since publication of the first edition, aburgeoning commerical industry has developed around various sourcesof perinatal cells, and the second edition now includes an overviewof this growing industry. With contributions from some of the top academic stem celllaboratories in the United States as well as new chapters frominternational stem cell scientists, Perinatal StemCells presents an update onthe cutting-edge research in the field whilemaintaining its signature clinical focus.

Perinatal Tissue Derived Stem Cells
Author: Babak Arjmand
Publisher: Springer
Release Date: 2016-12-01
Pages: 239
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Biomaterials And Stem Cells In Regenerative Medicine
Author: Murugan Ramalingam
Publisher: CRC Press
Release Date: 2012-07-03
Pages: 564
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

Exam Prep For  Perinatal Stem Cells
Author:
Publisher:
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
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Fetal Stem Cells In Regenerative Medicine
Author: Dario O. Fauza
Publisher: Springer
Release Date: 2016-05-02
Pages: 453
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

Adult Stem Cells
Author:
Publisher: Elsevier
Release Date: 2006-12-11
Pages: 576
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This is the second of three planned volumes in the Methods in Enzymology series on the topic of stem cells. This volume is a unique anthology of stem cell techniques focusing on adult stem cells, and written by experts from the top laboratories in the world. The contributors not only have hands-on experience in the field but often have developed the original approaches that they share with great attention to detail. The chapters provide a brief review of each field followed by a “cookbook and handy illustrations. The collection of protocols includes the isolation and maintenance of stem cells from various species using “conventional and novel methods, such as derivation of ES cells from single blastomeres, differentiation of stem cells into specific tissue types, isolation and maintenance of somatic stem cells, stem cell-specific techniques and approaches to tissue engineering using stem cell derivatives. The reader will find that some of the topics are covered by more than one group of authors and complement each other. Comprehensive step-by-step protocols and informative illustrations can be easily followed by even the least experienced researchers in the field, and allow the setup and troubleshooting of these state-of-the-art technologies in other laboratories. Provides complete coverage spanning from derivation/isolation of stem cells, and including differentiation protocols, characterization and maintenance of derivatives and tissue engineering Presents the latest most innovative technologies Addresses therapeutic relevance including FDA compliance and tissue engineering

Cell Therapy For Perinatal Brain Injury
Author: Haruo Shintaku
Publisher: Springer
Release Date: 2018-03-01
Pages: 150
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Cell And Molecular Biology And Imaging Of Stem Cells
Author: Heide Schatten
Publisher: John Wiley & Sons
Release Date: 2014-08-04
Pages: 304
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Cell and Molecular Biology and Imaging of Stem Cells features original and review articles written by experts who have made significant contributions to stem cell biology and imaging. Chapters cover a broad spectrum of aspects of the field, including Stem cells from the Amniotic Fluid and Placenta, Biomaterials as Artificial Niches for Pluripotent Stem Cell Engineering, Low-Intensity Ultrasound in Stem Cells and Tissue Engineering, Mammalian Neo-Oogenesis from Ovarian Stem Cells, Oct4-EGFP Transgenic Pigs as a New Tool for Visualization of Pluripotent and Reprogrammed Cells, Regulation of Adult Intestinal Stem Cells, Stem Cell Therapy for Veterinary Orthopedic Lesions, Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases, Hair Follicle Stem Cells, The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases, Mitochondrial Differentiation in Early Embryo Cells and Pluripotent Stem Cells, and The Role of Centrosomes in Cancer Stem Cell Functions. Cell and Molecular Biology and Imaging of Stem Cells addresses a wide variety of cell and molecular topics in unprecedented detail, and is a must-read for graduate students and academic and industry professionals in the expanding field of stem cell biology. Reviews new imaging tools and markers for cell and molecular imaging in stem cell biology. Covers novel aspects of stem cell imaging in reproductive biology and stem cell niches Includes chapters on the developing area of centrosome biology as it applies to embryonic and adult stem differentiation

Isolation  Characterization And Therapeutic Feasibility Of Human Umbilical Cord Derived Stem Cells
Author:
Publisher:
Release Date: 2017
Pages: 478
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Because of recent advances in stem cell research, cell therapies have gained increasing attention. Stem cells have shown promise to treat degenerative diseases and disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and degenerative disc disease. They are also being investigated to repair and regenerate skeletal tissues and structures. Pluripotent embryonic stem cells (ESCs) have the ability to differentiate into all of 200 types of cell in human body and have greatest potential for cell therapy. However, they face ethical and moral concerns. Whereas, adult stem cells (ASCs) such as bone marrow stromal cells (MSCs), hematopoietic stem cells (HSCs) are more acceptable for cell but they display limited proliferation and differentiation potential. Furthermore, ASCs may undergo genetic changes due to aging and environmental stress. Therefore, others and we have searched for alternative sources of cells for therapeutic usage. These efforts have led to discover stem cells (SCs) from perinatal tissues such as human umbilical blood and cord (UC). Not only, the SCs isolated from perinatal sources can be isolated non-invasively but also they are more primitive than ASCs. Current methods to isolate SCs from UC yield low amounts of cells with variable proliferation potential. Since, UC is an anatomically complex organ; we hypothesized that the variation in the SCs could be due to the difference in the various niches the UC harboring the SCs. In this study, we dissected the UC into its discrete parts, cord lining (CL), Wharton's jelly (WJ) and cord placenta junction (CPJ) and isolated SCs from each of these segments using explant culture technique. The isolated cells from all three sources displayed adherent fibroblastoid morphology, and not only expressed MSCs markers, CD29, CD44, CD73, CD90, and CD105 but also pluripotency genes, OCT4, NANOG, SOX2 and KLF4. They differentiated into multiple lineages such as adipogenic, chondrogenic and osteogenic cells. However, these cells displayed variations in their clonal capacity, ability to self-renew and differentiate depending upon the source of their isolation. SCs isolated from CPJ had highest rate of proliferation and greater capacity to self-renew and differentiate as compared to the SCs derived from CT and WJ. Microarray analysis confirmed the differences in these SCs based on the findings of differentially expressed genes between CPJ-, CL- and WJ-MSCs. We also found variation in the expression of IncRNA genes. Our studies demonstrated CJP as the sources of SCs with superior properties. These cells were then used for cell therapy and toxicological studies. Cell therapy feasability studies were conducted using CPJ-SCs and their chondrogenic derivatives, chondroprogenitor cells (CPCs) and nucleus pulposus (NP) like cells (NPCs) to regenerate damaged intervertebral disc (IVD) in a rabbit model. Degeneration of IVD results due to the loss of NP and is a common cause of lower back pain. Animal studies performed by transplanting CPJ-SCs and their derivatives showed significant improvement in the histology, cellularity, extracellular matrix proteins, and water and glycosaminoglycan contents of IVDs. Furthermore, the transplanted cells survived, engrafted and displayed homing into NP in situ. In addition, IVDs receiving CPJ-SCs derivatives exhibited higher expression of NP specific human markers, SOX9, ACAN, COL2, FOXF1, and KRT19. The regulation of the regeneration process and the NP biosynthesis was determined to be via TGF[beta]1/Smad pathway. Overall, the animal study showed that NPCs were is more efficacious than the CPCs and SCs. Our results provide basis and impetus for clinical studies to treat DDD as well as other degenerative diseases and disorders. Furthermore, these cells could be used for tissue engineering, regenerative medicine and pharmaceutical applications.

Fanaroff And Martin S Neonatal Perinatal Medicine
Author: Richard J. Martin
Publisher: Elsevier Health Sciences
Release Date: 2014-08-20
Pages: 1936
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.

Advances In Neonatal Neurology  An Issue Of Clinics In Perinatology
Author: Praveen Ballabh
Publisher: Elsevier Health Sciences
Release Date: 2014-02-22
Pages: 321
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

Placenta
Author: Taylor & Francis Group
Publisher: CRC Press
Release Date: 2021-03-30
Pages: 296
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Long regarded as biological waste, the placenta is gaining momentum as a viable product for clinical use. Due to their unique properties, placental cells and derivatives show great promise in curing various diseases. Utilizing contributions from world-renowned experts, Placenta: The Tree of Life considers the therapeutic potential of these cells. It examines new stem cell-based strategies and highlights recent studies that advance the range of treatment for a number of illnesses. Emphasizing the potential research and therapeutic use of stem cells, the book discusses the development, structure, and functions of the human placenta. It introduces overall aspects of the immune system, explains some of the immune mechanisms during pregnancy, and shows the role of the placenta in these mechanisms. Current scientific research is presented that focuses on the mechanisms of action underlying the therapeutic benefit of cells isolated from different placental regions. An exhaustive examination, this pivotal work: Considers how perinatal cells may represent an important source for cell therapy approaches in the near future, in both human and veterinary medicine Describes the clinical potential of placenta-derived cells in regenerative medicine--specifically in neurological disorders, metabolic liver diseases, inflammatory diseases, and autoimmune diseases Explains how cells isolated from different placental tissues share basic properties Placenta: The Tree of Life summarizes the advantages of perinatal tissue as a source of cells with therapeutic potential and is designed for use in the study of genetics, stem cell science, placental function, reproductive biology, regenerative medicine, and related fields.

Preventing Developmental Brain Injury     From Animal Models To Clinical Trials
Author: Masahiro Tsuji
Publisher: Frontiers Media SA
Release Date: 2019-10-23
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Selected Topics In Obstetrics And Gynaecology 4  For Postgraudate And Practitioners
Author: Daftary & Desai
Publisher: BI Publications Pvt Ltd
Release Date: 2008
Pages: 322
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Year Book Of Neonatal And Perinatal Medicine 2011   E Book
Author: Avroy A. Fanaroff
Publisher: Elsevier Health Sciences
Release Date: 2011-09-01
Pages: 328
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neontatology and perinatology, carefully selected from more than 500 journals worldwide. Dr. Avroy Fanaroff, Emeritus Professor as Case Western Reserve University, is a key opinion leader who has been a driving force in the field for many years. He authors many commentaries himself and has assembled top experts to select the most important journal articles and write commentaries that evaluate the clinical importance of each article and discuss its application to patient care. There's no faster or easier way to stay informed! This annual covers all aspects of care from the fetus, postnatal growth, labor and delivery, infectious diseases, respiratory disorders, cardiovascular health, and gastrointestinal health to name a few. The Year Book of Neonatal and Perinatal Medicine publishes annually in November.

Perinatal Brain Development  Malformation  And Injury
Author: Anne Penn
Publisher: Biota Publishing
Release Date: 2011-11-01
Pages: 84
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

We provide a broad overview of human brain development with associated malformations and injuries that occur in the period between early embryogenesis and delivery. The aim of this review is to summarize current understanding of the molecular and environmental cues that shape the developing brain. For each developmental stage, we give examples of disorders that arise from genetic and/or environmental insults to illustrate critical points of neurological susceptibility. Table of Contents: Introduction / Origin of the Central Nervous System: The Neural Tube (3-4 Weeks Gestation) / Patterning of the Neural Tube: A Blueprint for the CNS / Neural Proliferation and Migration (3 Months Gestation Into Postnatal Period) / Organization of Neuronal Circuits and Synaptogenesis (5 Months Gestation-Postnatal Years) / Gliogenesis and Myelination (5-Month Childhood) / Developmental Brain Injury: Before, During, and After Birth / Conclusion / References / Author Biographies

Hematopoietic Stem Cell Development In Placental Vasculature
Author: Katrin Elisabeth Rhodes
Publisher:
Release Date: 2009
Pages: 238
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS: