organic synthesis using biocatalysis

Organic Synthesis Using Biocatalysis
Author: Animesh Goswami
Publisher: Academic Press
Release Date: 2015-09-06
Pages: 438
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis In Organic Synthesis
Author: Nicholas J. Turner
Publisher: Royal Society of Chemistry
Release Date: 2018-02-08
Pages: 429
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Future Directions In Biocatalysis
Author: Tomoko Matsuda
Publisher: Elsevier
Release Date: 2011-08-11
Pages: 364
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In Future Directions in Biocatalysis the important topics within biocatalysis and enzymatic catalysis for organic synthesis are described for both experts and non-experts. This books focuses particularly on reactions under development at present and on future advances in the field. Consisting of four sections, this book examines enzymatic reactions under unusual conditions, unique biocatalytic reactions, synthesis of valuable compounds using biocatalysis and the latest molecular biology methods for biocatalysis. Each chapter deals with a specific theme and includes a summary of each area as well as the present state and future direction of research. * Describes methods for solving environmental issues through biocatalysis * Presents the integrated fields of biochemistry and organic chemistry * Unique research topics with high originality

Organic Synthesis With Enzymes In Non Aqueous Media
Author: Giacomo Carrea
Publisher: John Wiley & Sons
Release Date: 2008-04-09
Pages: 328
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Science Of Synthesis  Biocatalysis In Organic Synthesis Vol  1
Author:
Publisher: Georg Thieme Verlag
Release Date: 2015-03-11
Pages: 648
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" are designed to present the new possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to help start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As is the case with all of the Science of Synthesis volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including typical or general experimental procedures. The content organization of the three volumes is based on the type of reaction performed under biocatalysis. Volume 1 begins with chapters discussing the historical development of the field, sources of enzymes and appropriate selection of catalysts, and general strategies employed in biocatalysis. This is followed by reviews of the biocatalytic hydrolysis of various substrates. The volume concludes with chapters devoted to biocatalytic isomerizations, and the synthesis of glycosides.

Biocatalysis In Organic Synthesis
Author: Kurt Faber
Publisher: Thieme/Houben-Weyl Series
Release Date: 2015
Pages: 712
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Biocatalysts In Organic Synthesis
Author: Jan Halgas
Publisher: Elsevier Science Limited
Release Date: 1992
Pages: 334
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The fundamental problem in modern organic synthesis is the selectivity of preparative organic reactions. This book reflects the recent growth of interest in the use of biocatalysts to attain high chemo-, regio- and particularly, stereoselectivity. Enantiomerically pure compounds are required as building blocks for the synthesis of many new agrochemicals, drugs, or as bioorganic models and probes. The first two chapters are devoted to a brief description of basic properties of various forms of biocatalysts: free and immobilized enzymes, free and immobilized microbial cells and other biopreparations, e.g., monoclonal antibodies. The third chapter deals with different levels of selectivity of biocatalyzed reactions. Attention is paid mainly to the differentiation of enantiomers, enantiotopic groups and faces. The remaining six chapters cover particular types of organic reactions and some 939 references from recent original papers are given. These include substitution reactions, eliminations and additions, synthesis and hydrolysis of esters and amides, oxidations and reductions.Chemists specializing in the synthesis of new biologically active compounds, such as drugs, pesticides, insecticides, insect pheromones, food and cosmetic additives, etc., will find this book of immense value. The book will also be useful as a supplementary textbook for university graduate students taking courses on organic synthesis or bioorganic chemistry.

Science Of Synthesis  Biocatalysis In Organic Synthesis Vol  2
Author:
Publisher: Georg Thieme Verlag
Release Date: 2015-03-11
Pages: 672
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" are designed to present the new possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to help start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As is the case with all of the Science of Synthesis volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including typical or general experimental procedures. The content organization of the three volumes is based on the type of reaction performed under biocatalysis. Volume 2 covers reactions involving the formation of C-C bonds. Addition of carbon nucleophiles at C-O and C-N double bonds are reviewed, as are methods for the formation of C-C bonds at arenes and additions to C-C double bonds. Other chapters present transamination and reductive amination reactions, reduction of carbonyl compounds, and the chemistry of epoxides

Science Of Synthesis  Biocatalysis In Organic Synthesis Vol  3
Author: Kurt Faber
Publisher: Georg Thieme Verlag
Release Date: 2015-03-11
Pages: 712
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" present the possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As all SoS volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins by describing oxidation. A chapter on dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are also covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and the development of large-scale processes are considered. Finally, emerging trends are outlined.

Science Of Synthesis  Biocatalysis In Organic Synthesis
Author: Kurt Faber
Publisher:
Release Date: 2015
Pages: 712
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Biocatalysis For The Pharmaceutical Industry
Author: Junhua (Alex) Tao
Publisher: John Wiley & Sons
Release Date: 2009-07-23
Pages: 250
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalysis Using Plant And Metagenomic Enzymes For Organic Synthesis
Author: Sophie Alice Newgas
Publisher:
Release Date: 2018
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Biocatalysts And Enzyme Technology
Author: Klaus Buchholz
Publisher: John Wiley & Sons
Release Date: 2012-12-21
Pages: 626
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

Biocatalysis
Author: W.-D. Fessner
Publisher: Springer Science & Business Media
Release Date: 2003-09-05
Pages: 254
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Here, leading contributors from the forefront of this exciting technology present authoritative and timely reviews on the state of the art of biocatalysis. They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Enzyme Biocatalysis
Author: Andrés Illanes
Publisher: Springer Science & Business Media
Release Date: 2008-06-19
Pages: 392
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Selective Biocatalysis
Author: Laszlo Poppe
Publisher: Wiley-VCH
Release Date: 1992-07-06
Pages: 319
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

László Poppe, Lajos Novák Selective Biocatalysis A Synthetic Approach This stimulating monograph is a much needed response to the increasing use of biocatalysts in organic synthesis. In over 300 well-referenced pages, it reviews in detail applications and other aspects of the most widely used enzymes (e.g. hydrolases, oxidoreductases, and baker’s yeast) illustrates with examples the potential in biocatalysis of other, less frequently used enzymes and microorganisms discusses general problems of biocatalysis (e.g. stereochemistry of transformations, methods of influencing selectivity) indicates future trends in biocatalysis Researchers and students in prcparative organic chemistry. biotechnology and biochemistry will find this up-to-date monograph highly valuable in their daily work.

Asymmetric Organic Synthesis With Enzymes
Author: Vicente Gotor
Publisher: John Wiley & Sons
Release Date: 2008-03-31
Pages: 340
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Biocatalysis
Author: Peter Grunwald
Publisher: World Scientific Publishing Company
Release Date: 2009-03-02
Pages: 1052
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics. With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development. The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.

Biotransformations In Organic Chemistry
Author: Kurt Faber
Publisher: Springer Science & Business Media
Release Date: 2011-07-28
Pages: 423
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts—principles of stereoselective transformations, enzyme properties and kinetics—the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C–C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and modified or artificial enzymes, are treated in a separate section. A final chapter deals with thebasic rules for the safe and practical handling of biocatalysts. In this completely revised 6th edition, emphasis has been given to an improved didactic style including colored graphics in order to facilitate a deeper understanding of the underlying principles. New developments, such as transamination, enzyme promiscuity and applications on industrial scale within the field of 'white biotechnology' are included.

Modern Biocatalysis
Author: Wolf-Dieter Fessner
Publisher: John Wiley & Sons
Release Date: 2009-02-09
Pages: 400
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology structural biology and organic chemistry, thus highlighting the interdisciplinary nature of the subject. With its special focus on progress and new developments towards environmentally beneficial reactions with high levels of selectivity for the production of key compound classes, this book will enlighten both chemists and biologists as to the advances and opportunities existing in enzyme catalysis.