neuronal networks in brain function cns disorders and therapeutics

Neuronal Networks In Brain Function  CNS Disorders  And Therapeutics
Author: Carl Faingold
Publisher: Academic Press
Release Date: 2013-12-26
Pages: 512
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

New Therapeutics For Traumatic Brain Injury
Author: Kim Heidenreich
Publisher: Academic Press
Release Date: 2016-09-27
Pages: 352
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Models Of Seizures And Epilepsy
Author: Asla Pitkänen
Publisher: Academic Press
Release Date: 2017-06-14
Pages: 1178
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Tinnitus  Imaging  Endovascular And Surgical Approaches  An Issue Of Neuroimaging Clinics Of North America  E Book
Author: Prashant Raghavan
Publisher: Elsevier Health Sciences
Release Date: 2016-07-27
Pages: 145
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This issue of Neuroimaging Clinics of North America focuses on Imaging of Tinnitus. Articles will include: Neuroscience of Tinnitus; Clinical Evaluation of the Patient with Tinnitus; Arterial Abnormalities Leading to Tinnitus; Paragangliomas and Other Vascular Skull Base Tumors; Dural AV Fistulae: Imaging and Management; Venous Abnormalities Leading to Tinnitus: Imaging Evaluation; Endovascular Intervention in Venous Tinnitus: New Horizons and Future Directions; Emerging Role of Surgical Treatments in the Treatment of Tinnitus; Role of Advanced Neuroimaging and Future Directions; Imaging Interpretation of Temporal Bone Studies in a Patient with Tinnitus: A Systematic Approach; and much more!

Almost Periodicity  Chaos  And Asymptotic Equivalence
Author: Marat Akhmet
Publisher: Springer
Release Date: 2019-06-20
Pages: 360
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The central subject of this book is Almost Periodic Oscillations, the most common oscillations in applications and the most intricate for mathematical analysis. Prof. Akhmet's lucid and rigorous examination proves these oscillations are a "regular" component of chaotic attractors. The book focuses on almost periodic functions, first of all, as Stable (asymptotically) solutions of differential equations of different types, presumably discontinuous; and, secondly, as non-isolated oscillations in chaotic sets. Finally, the author proves the existence of Almost Periodic Oscillations (asymptotic and bi-asymptotic) by asymptotic equivalence between systems. The book brings readers' attention to contemporary methods for considering oscillations as well as to methods with strong potential for study of chaos in the future. Providing three powerful instruments for mathematical research of oscillations where dynamics are observable and applied, the book is ideal for engineers as well as specialists in electronics, computer sciences, robotics, neural networks, artificial networks, and biology. Distinctively combines results and methods of the theory of differential equations with thorough investigation of chaotic dynamics with almost periodic ingredients; Provides all necessary mathematical basics in their most developed form, negating the need for any additional sources for readers to start work in the area; Presents a unique method of investigation of discontinuous almost periodic solutions in its unified form, employed to differential equations with different types of discontinuity; Develops the equivalence method to its ultimate effective state such that most important theoretical problems and practical applications can be analyzed by the method.

Mechanisms Of Neuroinflammation
Author: Gonzalo Emiliano Aranda Abreu
Publisher: BoD – Books on Demand
Release Date: 2017-08-23
Pages: 318
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Brain And Art
Author: Bruno Colombo
Publisher: Springer Nature
Release Date: 2019-08-29
Pages: 182
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book analyzes and discusses in detail art therapy, a specific tool used to sustain health in affective developments, rehabilitation, motor skills and cognitive functions. Art therapy is based on the assumption that the process of making art (music, dance, painting) sparks emotions and enhances brain activity. Art therapy is used to encourage personal growth, facilitate particular brain areas or activity patterns, and improve neural connectivity. Treating neurological diseases using artistic strategies offers us a unique option for engaging brain structural networks that enhance the brain’s ability to form new connections. Based on brain plasticity, art therapy has the potential to increase our repertoire for treating neurological diseases. Neural substrates are the basis of complex emotions relative to art experiences, and involve a widespread activation of cognitive and motor systems. Accordingly, art therapy has the capacity to modulate behavior, cognition, attention and movement. In this context, art therapy can offer effective tools for improving general well-being, quality of life and motivation in connection with neurological diseases. The book discusses art therapy as a potential group of techniques for the treatment of neurological disturbances and approaches the relationship between humanistic disciplines and neurology from a holistic perspective, reflecting the growing interest in this interconnection.

Thinking About Cognition  Concepts  Targets And Therapeutics
Author: C.G. Kruse
Publisher: IOS Press
Release Date: 2006-12-19
Pages: 144
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

100 Years after the discovery of Alzheimer’s disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the brain. There seems to be consensus that on the background of aging, several factors may render humans prone to dementia. Psychiatric and neurological disorders such as schizophrenia, bipolar disorder or Parkinson’s disease may contribute to development of dementia. More people today are looking for help regarding their learning and memory capabilities. Although increasing knowledge on neuronal networks is transforming our view of the human brain and its function and we understand psychiatric and neurological diseases better today than ever before, novel therapies are needed to respond to the growing demand of patients for assistance with memory loss and learning impairment. In fact, it is expected that novel therapies aiming at the processing of amyloid, or at activation of glutamatergic or nicotinergic systems will demonstrate adequate efficacy in improving learning and memory disturbances. This publication stands as a comprehensive overview of the cellular and molecular mechanisms underlying the development of cognitive impairment. It integrates discoveries concerning dementia, such as mild cognitive impairment and Alzheimer’s disease associated dementia, vascular dementia, retardation syndromes, and psychiatric and neurological disorders related cognitive impairments. This book will be useful to physicians, biologists, and those pursuing an interest or concerned with memory impairment. 100 Years after the discovery of Alzheimer’s disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the brain. There seems to be consensus that on the background of aging, several factors may render humans prone to dementia. Psychiatric and neurological disorders such as schizophrenia, bipolar disorder or Parkinson’s disease may contribute to development of dementia. More people today are looking for help regarding their learning and memory capabilities. Although increasing knowledge on neuronal networks is transforming our view of the human brain and its function and we understand psychiatric and neurological diseases better today than ever before, novel therapies are needed to respond to the growing demand of patients for assistance with memory loss and learning impairment. In fact, it is expected that novel therapies aiming at the processing of amyloid, or at activation of glutamatergic or nicotinergic systems will demonstrate adequate efficacy in improving learning and memory disturbances. This publication stands as a comprehensive overview of the cellular and molecular mechanisms underlying the development of cognitive impairment. It integrates discoveries concerning dementia, such as mild cognitive impairment and Alzheimer’s disease associated dementia, vascular dementia, retardation syndromes, and psychiatric and neurological disorders related cognitive impairments. This book will be useful to physicians, biologists, and those pursuing an interest or concerned with memory impairment.

Brain Damage And Repair
Author: T. Herdegen
Publisher: Springer Science & Business Media
Release Date: 2004
Pages: 721
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Brain Damage and Repair aims to attract the interest of neuroscientists and clinical neurologists by building a novel bridge from molecular research to clinical therapy. This novel approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration. Comprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies. Brain Damage and Repair is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins.

Operative Neuromodulation
Author: Damianos E. Sakas
Publisher: Springer Science & Business Media
Release Date: 2007-12-03
Pages: 590
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This is the second part in a two-volume work on neuromodulation. It describes the techniques and procedures applied by direct contact with the central nervous system or cranial nerves (in order to modulate the function of neural networks) or in deeply located structures inside the nervous system (in order to alter the function on specific networks).

Issues In Neuroscience Research And Application  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 3141
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Mechanisms And Therapeutics In Neurodevelopmental Disorders
Author: Daniela Tropea
Publisher: Frontiers E-books
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across hitherto unrelated disorders- such as autism and schizophrenia- challenging how we conceptualize these conditions. These new discoveries call for the establishment of additional criteria for the classification of the genes and related phenotypes. Beyond the classical distinction according to diagnostic criteria, new parameters should be taken into account: the genetics, the neurobiology of the gene products and the molecular mechanisms that they control. Our broad understanding of NDDs, requires a combination of approaches, including human studies, animal models and theoretical computation. Indeed, progress in technology and the generation of accurate models are advancing the field, and the research is rapidly growing. This Research Topic presents recent advances in neurodevelopmental disorders from genes to systems, in single conditions and across different phenotypes, and report the newest treatments in use. Recognized experts in the field discuss recent findings in molecular studies, in vivo imaging, neuropsychology, neuropharmacology and computational neuroscience. This multidisciplinary approach enriches our understanding of the mechanisms involved in the onset and progression of NDDs with the perspective of revealing the biological signs of the disorders and identifying new therapeutics.

Pain Procedures In Clinical Practice E Book
Author: Ted A. Lennard
Publisher: Elsevier Health Sciences
Release Date: 2011-06-11
Pages: 656
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In the 3rd Edition of Pain Procedures in Clinical Practice, Dr. Ted Lennard helps you offer the most effective care to your patients by taking you through the various approaches to pain relief used in physiatry today. In this completely updated, procedure-focused volume, you’ll find nearly a decade worth of new developments and techniques supplemented by a comprehensive online video collection of how-to procedures at www.expertconsult.com. You’ll also find extensive coverage of injection options for every joint, plus discussions of non-injection-based pain relief options such as neuromuscular ultrasound, alternative medicines, and cryotherapy. Offer your patients today’s most advanced pain relief with nearly a decade worth of new developments and techniques, masterfully presented by respected physiatrist Ted Lennard, MD. Make informed treatment decisions and provide effective relief with comprehensive discussions of all of the injection options for every joint. Apply the latest non-injection-based treatments for pain relief including neuromuscular ultrasound, alternative medicines, and cryotherapy. See how to get the best results with a comprehensive video collection of how-to procedures at www.expertconsult.com, and access the complete text and images online.

Metabolic Control Of Brain Homeostasis
Author: Detlev Boison
Publisher: Frontiers Media SA
Release Date: 2017-10-03
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Brain function is under metabolic control, which in turn determines the equilibrium of homeostatic systems that affect neuronal and glial networks on the molecular, cellular, and systems levels. The collection of articles ranges from molecules and mechanisms involved in regulating homeostasis and neuronal excitability to therapeutic mechanisms tailored to restore homeostatic function. It also features neurological diseases and novel treatment approaches that are based on metabolic and homeostatic interventions. Together, the collection of articles outlines novel strategies to restore brain function in neurology and highlights limitations of conventional pharmacological approaches. We suggest that restoration of molecular and biochemical networks could lead to a new era of therapeutic opportunities.

Brain Repair
Author: Mathias Bähr
Publisher: Springer Science & Business Media
Release Date: 2007-03-06
Pages: 252
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts.

Transforming Growth Factor Beta In Cancer Therapy  Volume II
Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
Release Date: 2010-01-01
Pages: 786
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Rehabilitation Of Visual Disorders After Brain Injury
Author: Josef Zihl
Publisher: Psychology Press
Release Date: 2010-11-01
Pages: 288
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This thoroughly updated and extended edition covers the various cerebral visual disorders acquired after brain injury, as well as the rehabilitation techniques used to treat them. These are described within a brain plasticity framework, using data from single and group case studies along with follow up observation data. This original, tailor-made approach also includes the recording of eye movements for assessing scanning performance in scene perception and reading. The book gives a brief synopsis of the historical background on the subject, alongside an outline of intervention designs and methodological difficulties in the field, and goes on to discuss the mechanisms and processes that provide the foundations for recovery of function and successful adaptation in visually impaired patients. The author concludes by analyzing the importance of the procedures and outcomes of treatments to the reduction of patients’ visual handicaps. The new edition also contains an appendix with recommendations on the case histories, diagnostics and treatments. It is ideal reading for students in clinical neuropsychology, as well as professionals in the fields of neurology, visual neuroscience and rehabilitation experts.

Music  Brain  And Rehabilitation  Emerging Therapeutic Applications And Potential Neural Mechanisms
Author: Teppo Särkämö
Publisher: Frontiers Media SA
Release Date: 2016-08-05
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Music is an important source of enjoyment, learning, and well-being in life as well as a rich, powerful, and versatile stimulus for the brain. With the advance of modern neuroimaging techniques during the past decades, we are now beginning to understand better what goes on in the healthy brain when we hear, play, think, and feel music and how the structure and function of the brain can change as a result of musical training and expertise. For more than a century, music has also been studied in the field of neurology where the focus has mostly been on musical deficits and symptoms caused by neurological illness (e.g., amusia, musicogenic epilepsy) or on occupational diseases of professional musicians (e.g., focal dystonia, hearing loss). Recently, however, there has been increasing interest and progress also in adopting music as a therapeutic tool in neurological rehabilitation, and many novel music-based rehabilitation methods have been developed to facilitate motor, cognitive, emotional, and social functioning of infants, children and adults suffering from a debilitating neurological illness or disorder. Traditionally, the fields of music neuroscience and music therapy have progressed rather independently, but they are now beginning to integrate and merge in clinical neurology, providing novel and important information about how music is processed in the damaged or abnormal brain, how structural and functional recovery of the brain can be enhanced by music-based rehabilitation methods, and what neural mechanisms underlie the therapeutic effects of music. Ideally, this information can be used to better understand how and why music works in rehabilitation and to develop more effective music-based applications that can be targeted and tailored towards individual rehabilitation needs. The aim of this Research Topic is to bring together research across multiple disciplines with a special focus on music, brain, and neurological rehabilitation. We encourage researchers working in the field to submit a paper presenting either original empirical research, novel theoretical or conceptual perspectives, a review, or methodological advances related to following two core topics: 1) how are musical skills and attributes (e.g., perceiving music, experiencing music emotionally, playing or singing) affected by a developmental or acquired neurological illness or disorder (for example, stroke, aphasia, brain injury, Alzheimer’s disease, Parkinson’s disease, autism, ADHD, dyslexia, focal dystonia, or tinnitus) and 2) what is the applicability, effectiveness, and mechanisms of music-based rehabilitation methods for persons with a neurological illness or disorder? Research methodology can include behavioural, physiological and/or neuroimaging techniques, and studies can be either clinical group studies or case studies (studies of healthy subjects are applicable only if their findings have clear clinical implications).

Neurology Secrets E Book
Author: Joseph S. Kass
Publisher: Elsevier Health Sciences
Release Date: 2010-04-30
Pages: 486
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Revised and updated, Neurology Secrets, 5th Edition has the answers you need. A two-color page layout, portable size, and a list of the "Top 100 Secrets" in neurology help you better meet the challenges you face today. You’ll find all the features you rely on from the Secrets Series®—a question-and-answer format, lists, mnemonics, tables, and an informal tone—that make study or reference fast and easy. • Expedites reference and review with a question-and-answer format, bulleted lists, mnemonics, and practical tips from the authors. • Features a two-color page layout, "Key Points" boxes, and lists of useful web sites to enhance your reference power. • Presents a chapter containing "Top 100 Secrets," providing you with a quick and concise overview of essential material for last-minute study or self-assessment. • Fits comfortably in the pocket of your lab coat to allow quick access to essential information when you need it the most. • Presents completely revised chapters, covering all of today's most common neurologic conditions and their treatment to keep you up to date.

NMC
Author:
Publisher:
Release Date: 1998
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Contains the proceedings of the 12th- annual meeting of the Japan Neurosurgical Society.