molecular biological markers for toxicology and risk assessment

Molecular Biological Markers For Toxicology And Risk Assessment
Author: Bruce A. Fowler
Publisher: Academic Press
Release Date: 2016-06-10
Pages: 164
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Genetic Toxicology And Cancer Risk Assessment
Author: Wai Nang Choy
Publisher: CRC Press
Release Date: 2001-08-31
Pages: 406
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Computational Toxicology
Author: Bruce A. Fowler
Publisher: Academic Press
Release Date: 2013-06-04
Pages: 274
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Biologic Markers In Urinary Toxicology
Author: National Research Council
Publisher: National Academies Press
Release Date: 1995-08-28
Pages: 322
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Environmental Toxicology And Risk Assessment
Author: Diane S. Henshel
Publisher: ASTM International
Release Date: 1996
Pages: 476
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Molecular  Clinical And Environmental Toxicology
Author: Andreas Luch
Publisher: Springer Science & Business Media
Release Date: 2012-06-07
Pages: 574
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Scientific Frontiers In Developmental Toxicology And Risk Assessment
Author: National Research Council
Publisher: National Academies Press
Release Date: 2000-11-21
Pages: 354
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Toxicologic Biomarkers
Author: Anthony P. DeCaprio
Publisher: CRC Press
Release Date: 2006-04-18
Pages: 312
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical s

Encyclopaedia Of Occupational Health And Safety  The Body  Health Care  Management And Policy  Tools And Approaches
Author: Jeanne Mager Stellman
Publisher: International Labour Organization
Release Date: 1998
Pages: 1174
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities.

Molecular Toxicology Protocols
Author: Phouthone Keohavong
Publisher: Springer Science & Business Media
Release Date: 2005
Pages: 489
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

New state-of-the-art molecular techniques promise to transform the field of genetic toxicology by making it possible to directly detect genotoxic exposures and their consequences in humans, to identify the agent(s) involved, and to clinically manage the exposed population. In Molecular Toxicology Protocols, researchers from prominent universities and cancer centers around the world describe in detail their best techniques for analyzing genotoxic exposure and the resulting biological effects, including intermediate biomarkers such as DNA and chromosomal damage, mutations in reporter and oncogenes, and the earliest possible detection of cancer. The authors emphasize analytical methods specifically developed for use in human populations and in cancer patients, or in other in vivo systems such as transgenic mice. Among the applications detailed are the analysis of interactions of chemical and physical agents with cellular macromolecules, especially DNA, the assessment of medically relevant toxicity, and the individualized characterization of genetic damage and repair. There are also methods to assess and characterize the modulation of this damage and repair through individual differences in specific and genome-wide gene expression, including metabolic profiling and apoptotic capacity. These methods mark a shift in emphasis from studies of the agents themselves to the exposed population, and from studies of small populations with significant known exposures to a single agent, to studies of common diseases, such as breast cancer, caused by normal levels of generalized genotoxic exposure. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Molecular Toxicology Protocols offers a gold-standard collection of cutting-edge techniques designed to investigate a broad range of exposures-endogenous, accidental, medical, environmental, and occupational-and their role in human carcinogenesis and other diseases of aging.

Toxicology And Risk Assessment
Author: Helmut Greim
Publisher: John Wiley & Sons
Release Date: 2008-04-15
Pages: 698
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.

Molecular Biology Of The Toxic Response
Author: Alvaro Puga
Publisher: CRC Press
Release Date: 1998-10-14
Pages: 581
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Encouraging the incorporation of molecular biology techniques into the experimental approach to various toxicological problems, the format of the book is two-staged. Each chapter first introduces how various molecular techniques can be successfully applied to solving a specific toxicology question and proceeds to describe the techniques themselves. Also included is a discussion of the benefits and limitations of these techniques . This book will prove of value to practising researchers, but also to graduate students dealing with conceptual issues relating to molecular toxicology.

Ecological Biomarkers
Author: Claude Amiard-Triquet
Publisher: CRC Press
Release Date: 2016-04-19
Pages: 464
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Does a change, which affects a few biological macro-molecules, some cells, or a few individuals within a population, have any ecological significance that would allow the prediction of deleterious effects at higher levels of biological organization, namely the population, community, and ultimately the ecosystem? With contributions from experts in the field, Ecological Biomarkers: Indicators of Ecotoxicological Effects explores how biomarkers can be used to predict effects farther down the chain. It presents a synthesis of the state of the art in the methodology of biomarkers and its contribution to ecological risk assessment. This book describes the core biomarkers currently used in environmental research concerned with biological monitoring, biomarkers which correspond to the defences developed by living organisms in response to contaminants in their environment, and biomarkers that reveal biological damage resulting from contaminant stressors. It examines the efficacy of lysosomal biomarkers, immunotoxicity effects, behavioral disturbances, energy metabolism impairments, endocrine disruption measures, and genotoxicity as all indicative of probable toxic effects at higher biological levels. It is time to revisit the biological responses most ecologically relevant in the diagnosis of the health status of an aquatic environment well before it becomes unmanageable. Biomarkers provide a real possibility of delivering an easily measured marker at a simple level of biological organization that is predictably linked to a potentially ecologically significant effect at higher levels of biological organization. The text explores the latest knowledge and thinking on how to use biomarkers as tools for the assessment of environmental health and management.

Environmental Toxicology And Risk Assessment
Author: Diane Susan Henshel
Publisher: ASTM International
Release Date: 1999
Pages: 495
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Handbook On The Toxicology Of Metals
Author: Monica Nordberg
Publisher: Elsevier
Release Date: 2011-04-28
Pages: 1024
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

Environmental Toxicology And Risk Assessment
Author: Wayne G. Landis
Publisher: ASTM International
Release Date: 1993
Pages: 431
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Introduction To Ecotoxicology
Author: Des W. Connell
Publisher: John Wiley & Sons
Release Date: 2009-07-17
Pages: 184
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Environmental pollution is one of the most serious threats to the future health of our planet. A wide and ever increasing range of chemicals from industry, agriculture, medicine and a host of other sources continue to contribute to the earth's chemical load. Governments have encountered great difficulties responding to the crucial and immediate need for effective management. As a result, the new science of ecotoxicology has developed, which provides a broad conceptual framework for evaluating the effects of chemicals in natural ecosystems. This book is aimed principally at undergraduate students who have completed basic courses in both chemistry and biology. It takes a broad view of ecotoxicology starting with the nature, properties and behaviour of environmental toxicants, and extends to dose/response relationships and effects on organisms, populations, communities and ecosystems. Importantly, it also addresses environmental management areas such as biomarkers, biomonitoring, ecological risk assessment and the ecotoxicology and management of chemicals. The book provides an invaluable overview of the subject for students taking courses in ecotoxicology and environmental pollution, as well as wider degree programmes in biology, ecology, wildlife management, environmental science, environmental impact assessment, toxicology, pollution, chemical engineering, civil engineering, sanitation engineering and related subjects.

Male Mediated Developmental Toxicity
Author: Andrew F. Olshan
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 406
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Toxicology Abstracts
Author:
Publisher:
Release Date: 1993
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Includes annual author and subject indexes.

Encyclopedia Of Human Biology
Author: Renato Dulbecco
Publisher:
Release Date: 1997
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS: