genomic control process

Genomic Control Process
Author: Isabelle Peter
Publisher: Academic Press
Release Date: 2015-01-21
Pages: 460
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

The Regulatory Genome
Author: Eric H. Davidson
Publisher: Elsevier
Release Date: 2010-07-19
Pages: 304
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams

Decoding The Genomic Control Of Immune Reactions
Author: Gregory R. Bock
Publisher: John Wiley & Sons
Release Date: 2007-04-04
Pages: 232
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Philosophy Of Systems Biology
Author: Sara Green
Publisher: Springer
Release Date: 2016-12-15
Pages: 265
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.

Introduction To Genomic Signal Processing With Control
Author: Aniruddha Datta
Publisher: CRC Press
Release Date: 2018-10-08
Pages: 288
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms. The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state. Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.

The Fractal Brain Theory
Author: Wai Tsang
Publisher: Lulu.com
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Echinoderms
Author:
Publisher: Academic Press
Release Date: 2019-04-02
Pages: 550
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems Highlights new advances in the field, with this update presenting interesting chapters on echinoderms

Genomic Regulatory Systems
Author: Eric H. Davidson
Publisher: Elsevier
Release Date: 2001-01-24
Pages: 261
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Cancer  Cell Structures  Carcinogens And Genomic Instability
Author: Leon P. Bignold
Publisher: Springer Science & Business Media
Release Date: 2006
Pages: 375
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Genome Evolution
Author: Axel Meyer
Publisher: Springer Science & Business Media
Release Date: 2003-04-30
Pages: 237
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Table of contents

New Research On Genomic Instability
Author: Eleanor J. Gloscow
Publisher: Nova Publishers
Release Date: 2007
Pages: 302
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Many cancer biologists now believe that genomic instability not only initiates carcinogenesis, but also allows the tumour cell to become metastatic and evade drug toxicity. The loss of stability of the genome is becoming accepted as one of the most important aspects of carcinogenesis. One of the hallmarks of the cancer cell is the inherent instability of its genome. This book presents important research in this exciting field.

Geogenomics
Author: Vladimir Kirillovich Savchenko
Publisher: Cpl Press
Release Date: 2009
Pages: 294
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"Geogenomics - Organisation of the Genosphere" develops further an associative and integrative view on the genetic component of the biosphere established in two previous monographs "The Genosphere: the genetic system of the biosphere" the Russian version of which was published in 1991 and English version in 1997 (Savchenko, 1991; Sauchanka, 1997) and "Coenogenetics: genetics of biotic communities" (Sauchanka, 2001, 2002). These works were based on the system methodology and were oriented towards building the bridge between modern system biology including its molecular, organisms and population levels and the planetary system science. The system approach gives the possibility for the emerging geogenomics to mobilise, absorb and integrate the vast data produced by classical genetics and its new molecular branches such as genomics and proteomics for elucidation and understanding of the global planetary role of existing diversity of species genomes in their concerted interactions within local and regional ecosystems. Finally each genome consists of the genetic information defining the species' role in the biosphere i.e. whether it will be producer, consumer or decomposer and where their distribution area within the biosphere will be spread - in the equatorial tropical forests or in the polar tundra. The book includes chapters covering Earth System and Biodiversity; Biosphere Genetics; Genosphere; Coenogenomics and Coenogenomic Cooperation, Exploitation and Competition; Species Genome, Horizontal Transfer and Genome Modification; Phylogenomic Tree; Genosphere Self-Organisation and Complexity.

The OMICs
Author: Giovanni Coppola
Publisher: Oxford University Press
Release Date: 2013-12-11
Pages: 272
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.

Genomics And Proteomics Engineering In Medicine And Biology
Author: Metin Akay
Publisher: John Wiley & Sons
Release Date: 2006-10-09
Pages: 450
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Current applications and recent advances in genomics and proteomics Genomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding. Topics discussed include: Qualitative knowledge models Interpreting micro-array data Gene regulation bioinformatics Methods to analyze micro-array Cancer behavior and radiation therapy Error-control codes and the genome Complex life science multi-database queries Computational protein analysis Tumor and tumor suppressor proteins interactions

The World Of The Cell
Author: Wayne M. Becker
Publisher: Longman Publishing Group
Release Date: 2000
Pages: 878
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book is intended as a comprehensive introduction to cellular and molecular biology for students preparing for careers in biology, medicine and related fields. Its goal is to present essential principles, processes and methodology.

Pediatric Allergy  Principles And Practice E Book
Author: Donald Y. M. Leung
Publisher: Elsevier Health Sciences
Release Date: 2010-10-13
Pages: 704
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.

Evolutionary Developmental Biology
Author: Brian K. Hall
Publisher: Springer Science & Business Media
Release Date: 1999-08-31
Pages: 491
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Although evolutionary developmental biology is a new field, its origins lie in the last century; the search for connections between embryonic development (ontogeny) and evolutionary change (phylogeny) has been a long one. Evolutionary developmental biology is however more than just a fusion of the fields of developmental and evolutionary biology. It forges a unification of genomic, developmental, organismal, population and natural selection approaches to evolutionary change. It is concerned with how developmental processes evolve; how evolution produces novel structures, functions and behaviours; and how development, evolution and ecology are integrated to bring about and stabilize evolutionary change. The previous edition of this title, published in 1992, defined the terms and laid out the field for evolutionary developmental biology. This field is now one of the most active and fast growing within biology and this is reflected in this second edition, which is more than twice the length of the original and brought completely up to date. There are new chapters on major transitions in animal evolution, expanded coverage of comparative embryonic development and the inclusion of recent advances in genetics and molecular biology. The book is divided into eight parts which: place evolutionary developmental biology in the historical context of the search for relationships between development and evolution; detail the historical background leading to evolutionary embryology; explore embryos in development and embryos in evolution; discuss the relationship between embryos, evolution, environment and ecology; discuss the dilemma for homology of the fact that development evolves; deal with the importance of understanding how embryos measure time and place both through development and evolutionarily through heterochrony and heterotrophy; and set out the principles and processes that underlie evolutionary developmental biology. With over one hundred illustrations and photographs, extensive cross-referencing between chapters and boxes for ancillary material, this latest edition will be of immense interest to graduate and advanced undergraduate students in cell, developmental and molecular biology, and in zoology, evolution, ecology and entomology; in fact anyone with an interest in this new and increasingly important and interdisciplinary field which unifies biology.

Ultrasound In Obstetrics And Gynaecology
Author: Hylton B. Meire
Publisher:
Release Date: 2001
Pages: 688
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Volume 3 of the superb 3-volume set represents today's most exquisitely illustrated and authoritative source on obstetric and gynecologic ultrasound imaging. It includes comprehensive coverage of color Doppler, power Doppler, interventional ultrasound, and laparoscopic ultrasound. With over 1110 illustrations, it details all the most recent advances. Spanish version also available, ISBN: 84-8174-561-8

The Dome Of Eden
Author: Stephen H. Webb
Publisher: Wipf and Stock Publishers
Release Date: 2010-01-01
Pages: 374
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

What would biology look like if it took the problem of natural evil seriously? This book argues that biological descriptions of evolution are inherently moral, just as the biblical story of creation has biological implications. A complete account of evolution will therefore require theological input. The Dome of Eden does not try to harmonize evolution and creation. Harmonizers typically begin with Darwinism and then try to add just enough religion to make evolution more palatable, or they begin with Genesis and pry open the creation account just wide enough to let in a little bit of evolution. By contrast, Stephen Webb provides a theory of how evolution and theology fit together, and he argues that this kind of theory is required by the internal demands of both theology and biology. The Dome of Eden also develops a theological account of evolution that is distinct from the intelligent design movement. Webb shows how intelligent design properly discerns the inescapable dimension of purpose in nature but, like Darwinism itself, fails to make sense of the problem of natural evil. Finally, this book draws on the work of Karl Barth to advance a new reading of the Genesis narrative and the theology of Duns Scotus to provide the necessary metaphysical foundation for evolutionary thought.

Transposons And The Dynamic Genome
Author: Dirk-Henner Lankenau
Publisher: Springer Science & Business Media
Release Date: 2009-06-30
Pages: 184
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life.