estrogen effects on traumatic brain injury

Estrogen Effects On Traumatic Brain Injury
Author: Kelli A Duncan
Publisher: Academic Press
Release Date: 2014-12-29
Pages: 172
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury. Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results. A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection. Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other. Written to provide clinicians with new and developing treatment options for patients in their field.

New Therapeutics For Traumatic Brain Injury
Author: Kim Heidenreich
Publisher: Academic Press
Release Date: 2016-09-27
Pages: 352
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Brain Injury Medicine
Author: Nathan Zasler
Publisher: Demos Medical Publishing
Release Date: 2007
Pages: 1275
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Covers the full continuum from early diagnosis and evaluation through rehabilitation, post-acute care, and community re-entry. Includes assessment and treatment, epidemiology, pathophysiology, neuroanatomy, neuroimaging, the neuroscientific basis for rehabilitation, ethical and medicolegal issues, life-care planning, and more.

Traumatic Brain Injury
Author: Mark J. Ashley
Publisher: CRC Press
Release Date: 2016-04-19
Pages: 1084
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Since the bestselling second edition was published almost a decade ago, the field of brain injury treatment has undergone tremendous change, largely impacting access to treatment. But, while the healthcare marketplace has evolved, the needs of brain injury victims remain the same. With updated and expanded clinical coverage, Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition delineates a broad spectrum of advanced theoretical clinical constructs and detailed diagnostic and treatment interventions for traumatic brain injury. Details Specific Diagnostic and Treatment Approaches for Nearly All Aspects of Dysfunction Observed Following Brain Injury With contributions from more than 50 authorities in both academia and industry, this highly respected text stands apart as a clinical guide to rehabilitative treatment of persons with traumatic brain injury following the acute phase of treatment. It provides a concise source of information about the scientific and therapeutic realms involved in the rehabilitation of a person with traumatic brain injury, specifically as they relate to persistent deficits. The book also details long-term consequences of brain injury and effective approaches to vocational rehabilitation and case management. Widening coverage from the previous edition, this book includes details on: Metabolic and bioenergetic factors in brain injury Neuroendocrine dysfunction following brain injury Blast injury Ethical issues in treatment of brain injury Neuropharmacological and neuropsychological interventions following brain injury Interventions for the minimally conscious patient Dietary and exercise considerations after brain injury Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition is a complete source of pharmacological, anatomical, and physiological information for basic therapeutic rationales that are often not well understood in the field. It is an ideal reference for both new and experienced clinicians.

Traumatic Brain Injury In Sports
Author: Mark Lovell
Publisher: CRC Press
Release Date: 2004-01-01
Pages: 520
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Traumatic brain injury (TBI) in sports has become an important international public health issue over the past two decades. However, until recently, return to play decisions following a sports-related traumatic brain injury have been based on anecdotal evidence and have not been based on scientifically validated clinical protocols. Over the past decade, the field of Neuropsychology has become an increasingly important component of the return to play decision making process following TBI. Neuropsychological assessment instruments are increasingly being adapted for use with athletes throughout the world and the field of sports neuropsychology appears to be a rapidly evolving subspecialty. This book provides a comprehensive overview of the application of neuropsychological assessment instruments in sports, and it is structured to present a global perspective on contemporary research. In addition to a review of current research, Traumatic Brain Injury in Sports: An International Neuropsychological Perspective, presents a thorough review of current clinical models that are being implemented internationally within American and Australian rules football, soccer, boxing, ice hockey, rugby and equestrian sports.

Estrogen     Mystery Drug For The Brain
Author: Christian Behl
Publisher: Springer Science & Business Media
Release Date: 2011-06-28
Pages: 231
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and therefore "from bench to bed”.

Estradiol  Synthesized By Reactive Glia  Is A Potent Anti Inflammatory In The Injured Vertebrate Brain
Author: Alyssa Pedersen
Publisher:
Release Date: 2015
Pages: 27
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Neuroinflammation following traumatic brain injury (TBI) may have detrimental and beneficial effects that likely differ between the acute and chronic periods post-trauma. In birds and mammals, traumatic brain injury increases the expression of cytokines in microglia and aromatase ( estrogen synthase) in astroglia. In the songbird, TBI-induced synthesis of estrogens by glial aromatization is neuroprotective as aromatase inhibition and replacement with estradiol (E2) exacerbates and mitigates the extent of damage and apoptosis, respectively. The effect of glial estrogens on inflammation, however, remains unstudied. We hypothesized that induced astrocytic aromatization may affect neuroinflammation following TBI, via the synthesis of neural E2 around the site of damage. In three separate experiments on adult zebra finches (Taeniopygia guttata) of both sexes we tested the influence of (a) mechanical TBI, (b) inhibition of induced aromatase expression, and (c) inhibition of induced aromatase with central E2 replacement, on the expression of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-6, and aromatase. At 2-hour post-injury, in both sexes, TBI increased, and tended to elevate, TNFalpha and IL-1beta respectively. At 24-hour post-injury, also in both sexes, cytokines appeared to have returned to baseline, but aromatase is robustly elevated in the lobe that sustained TBI. Pharmacological inhibition of induced aromatization resulted in persistent neuroinflammation, as administration of fadrozole increased IL-1beta in females and TNFalpha in males 24 hour following TBI. This prolonged neuroinflammation following aromatase inhibition appears to be due to a failure to synthesize E2 locally, since E2 replacement lowered TNFalpha and IL-1beta relative to fadrozole alone. IL-6 was not affected by TBI, aromatase inhibition or E2 replacement in either sex. These data suggest that astrocytic E2 synthesis following TBI is a potent and inducible anti-inflammatory signal, with specific modulation of discrete cytokine signaling. Induced neural provision of E2 following damage and compromise of central pathways may protect the brain from the deleterious effects of prolonged neuroinflammation.

Trauma Intensive Care
Author: Samuel A. Tisherman
Publisher: Oxford University Press
Release Date: 2013-07-11
Pages: 336
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An ideal resource for intensivists caring for trauma victims in the ICU, Trauma Intensive Care provides point-of-care guidelines for establishing the priorities of care, minimizing complications, and returning patients to the best possible functional outcome.

Year Book Of Emergency Medicine 2012   E Book
Author: Richard J Hamilton
Publisher: Elsevier Health Sciences
Release Date: 2012-05-08
Pages: 336
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Year Book of Emergency Medicine brings you abstracts of the articles that reported the year's breakthrough developments in emergency medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Topics covered in the 2012 edition include Trauma, Resuscitation, Cardiovascular Emergencies, Gastrointestinal Emergencies, Infections and Immunologic Disorders, Neurology, and Pediatric Emergency Medicine. Focused, fast, and insightful information for the busy Emergency Room Physician!

Estradiol Congeners   Advances In Research And Application  2012 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-12-26
Pages: 157
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Estradiol Congeners—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Estradiol Congeners. The editors have built Estradiol Congeners—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Estradiol Congeners in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Estradiol Congeners—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Spinal Cord Medicine  Second Edition
Author: Christopher M. Bono, MD
Publisher: Demos Medical Publishing
Release Date: 2010-03-19
Pages: 560
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A Doody's Core Title 2012 The thoroughly revised Second Edition of this authoritative reference continues to define the standard of care for the field of spinal cord medicine. Encompassing all of the diseases and disorders that may a!ect the proper functioning of the spinal cord or spinal nerves, this comprehensive volume provides a state of the art review of the principles of care and best practices for restoring function and quality of life to patients with spinal cord injuries. Expert contributors from multiple disciplines cover topics ranging from acute medical and surgical management of specific problems to cutting-edge research, bladder, bowel and sexual dysfunction, neurologic and musculoskeletal issues, advanced rehabilitation techniques and technologies, functional outcomes, and psychosocial care. While comprehensive in scope, Spinal Cord Medicine offers practical guidance for physicians and other health care professionals involved in the management of individuals with SCI, multiple sclerosis, and other spinal cord disorders. The Second Edition has been completely updated to fully reflect current science and practice. Each section has been re-ordered to better present information and the Second Edition brings in many new authors and topics, more diagrams, illustrations, and tables to solidify concepts, and contains 18 entirely new chapters. Spinal Cord Medicine: Principles and Practice, Second Edition, reflects the breadth and depth of this multi-faceted specialty. Involving over 150 authors from more than 20 fields of medicine, it is a trusted reference for anyone who works with spinal cord patients and strives to deliver superior clinical care and improve outcomes.

Physical Medicine And Rehabilitation E Book
Author: Randall L. Braddom
Publisher: Elsevier Health Sciences
Release Date: 2010-12-07
Pages: 1472
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Physical Medicine and Rehabilitation presents today’s best physiatry knowledge and techniques, ideal for the whole rehabilitation team. This trusted reference delivers the proven science and comprehensive guidance you need to offer every patient maximum pain relief and optimal return to function. In this new edition, Dr. Randall L. Braddom covers current developments in interventional injection procedures, the management of chronic pain, integrative medicine, recent changes in the focus of stroke and brain injury rehabilitation, and much more. Access the complete contents online along with 1000 self-assessment questions at www.expertconsult.com. Gain a clear visual understanding of important concepts thanks to 1400 detailed illustrations—1000 in full color. Find and apply the information you need easily with each chapter carefully edited by Dr. Braddom and his associates for consistency, succinctness, and readability. Access the fully searchable text online at Expert Consult, as well as 1000 self-assessment questions. Master axial and peripheral joint injections through in-depth coverage of the indications for and limitations of these therapies. Make optimal use of ultrasound in diagnosis and treatment. Get a broader perspective on your field from a new chapter on PM&R in the international community.

Neurotrauma And Critical Care Of The Brain
Author: Jack Jallo
Publisher: Thieme
Release Date: 2018-04-04
Pages: 432
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"This book really is a complete primer on the head injured patient. Without a map such as the one this book metaphorically provides, the voyage to mastery can be hazardous for both practitioner and patient."— Journal of the American Medical Association Neurotrauma and Critical Care of the Brain, 2nd edition by renowned neurosurgeons Jack Jallo and Christopher Loftus incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on traumatic brain injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery provide a concise review of a complex and evolving field. The book lays a solid foundation with discussion of TBI classification, pathophysiology, key blood biomarkers, noninvasive neuromonitoring in severe TBI patients, multimodality monitoring in neurocritical care, and brain imaging modalities. From the prehospital setting to intensive care, top experts share clinical pearls and core guidelines on the management of mild, moderate, and severe TBI and complications. Chapters new to this edition include concomitant injuries, orbital/facial fractures, vascular injuries, spine fractures, autonomic dysfunction, and temperature management. Key Highlights Specialized topics include wartime penetrating injuries, cardiovascular complications of TBI, venous thromboembolism prophylaxis, ethical considerations, TBI costs in the U.S. and the financial return on helmets Management of pediatric brain injuries in the NICU with illustrative cases Nearly 200 high quality illustrations facilitate understanding of complex anatomy and techniques Summary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalities This remarkable resource is essential reading for neurosurgeons, neurologists, trauma physicians, critical care and rehabilitation medicine specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Spine, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.

Pfizer Global Research And Development Scientific Publications  2000
Author:
Publisher:
Release Date: 2000
Pages: 408
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Pediatric Neurocritical Care
Author: Nicholas S. Abend, MD
Publisher: Demos Medical Publishing
Release Date: 2012-11-28
Pages: 350
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"Pediatric Neurocritical Care is by far the most comprehensive book I have read dealing with this topic... This text will provide an excellent reference for those interested in the pediatric intensive care cases or pediatrics in general. It is written very well and is chock-full of information that Practioners in a pediatric ICU setting would use." --Donna Jacobs, R. EEG T., CNIM, The Neurodiagnostic Journal Caring for children with neurocritical illness often requires multi-specialty collaboration and the understanding of an ever-expanding body of data. This book gives clinicians the up-to-date, concise, and clinically relevant guidance they need to provide optimal care to children with these acute neurologic disorders. The chapters in Pediatric Neurocritical Care are authored by experts in each individual topic, and co-edited by a neurologist and intensivist to ensure that all topics have been fully addressed from both perspectives. The book covers the complete continuum of care from assessment, monitoring, and condition specific management through rehabilitation. Early chapters present differential diagnosis and management approaches to common overarching problems such as coma, headache, and elevated intracranial pressure, followed by chapters focusing on the evaluation and management of specific conditions including traumatic brain injury, stroke, seizures, central nervous system infections, and demyelinating disorders. The final chapters address important associated psychological, social, and ethical issues. To reflect the full spectrum of specialties involved in the burgeoning field of pediatric neurocritical care, the book brings together an international group of experts from multiple disciplines including critical care medicine, anesthesiology, neurology, neurosurgery, rehabilitation medicine, psychology, and pediatric subspecialties. Pediatric Neurocritical Care features: Every topic is addressed from a neurologic and critical care perspective. Comprehensive coverage includes the evaluation of common overarching problems and management of specific conditions, in addition to discussion of related psychological, ethical, and social issues. Chapters are written by internationally known experts from the fields of critical care medicine, anesthesiology, neurology, neurosurgery, rehabilitation medicine, and many affiliated specialties.

CSA Neurosciences Abstracts
Author:
Publisher:
Release Date: 1999
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Recent Advances And Future Directions In Trauma Care  An Issue Of Surgical Clinics   E Book
Author: Jeremy W. Cannon
Publisher: Elsevier Health Sciences
Release Date: 2012-08-19
Pages: 240
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An important review on trauma for the general surgeon! Topics include spectrum of TBI from mild to severe, management of complex extremity injuries, long-range ICU transport, advanced technologies in trauma/CC management, non-compressible torso hemorrhage, trauma system configurations in other countries, graduate medical education in trauma/CC and acute care surgery, improving care in the trauma ICU, damage control surgery, massive transfusion and damage control resuscitation, burn/electrical/environmental injury resuscitation, pre-hospital management and tactical combat casualty care, research and analytics in trauma care, verification and regionalization of trauma systems, and more!

Stroke E Book
Author: J. P. Mohr
Publisher: Elsevier Health Sciences
Release Date: 2011-05-13
Pages: 1520
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.

Effects Of Chronic Estrogen Exposure On Catecholaminergic Activity In The Preoptico Suprachiasmatic Tuberoinfundibular System Governing The Regulation Of Luteinizing Hormone Surge In Rats
Author: Badrinarayanan Seshadri Kasturi
Publisher:
Release Date: 2005
Pages: 350
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Manual Of Traumatic Brain Injury Management
Author: Felise S. Zollman, MD, FAAN, FAAMA
Publisher: Demos Medical Publishing
Release Date: 2011-03-24
Pages: 518
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Pocket-sized and portable, the Manual of Traumatic Brain Injury Management provides relevant clinical information in a succinct, readily accessible format. Expert authors drawn from the fields of rehabilitation medicine, neurology, neurosurgery, neurophysiology, physical and occupational therapy, and related areas cover the range of TBI, from concussion to severe injury. Organized to be consistent with the way TBI is managed, the book is divided into six sections and flows from initial injury through community living post-TBI, allowing clinicians to key in on specific topics quickly. Manual of Traumatic Brain Injury Management delivers the information you need to successfully manage the full spectrum of issues, medical complications, sequelae, and rehabilitation needs of patients who have sustained any level of brain injury. Features of Manual of Traumatic Brain Injury Management Include: Concise yet comprehensive: covers all aspects of TBI and its management A clinically-oriented, practical "how-to" manual, designed for rapid access to key information Organized to be consistent with the way TBI is managed Includes dedicated chapters on TBI in athletes and in military personnel. Internationally known contributors drawn from the leading TBI programs provide expert information