essential pharmacokinetics

Essential Pharmacokinetics
Author: Thorsteinn Loftsson
Publisher: Academic Press
Release Date: 2015-03-25
Pages: 178
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Handbook Of Essential Pharmacokinetics  Pharmacodynamics And Drug Metabolism For Industrial Scientists
Author: Younggil Kwon
Publisher: Springer Science & Business Media
Release Date: 2007-05-08
Pages: 291
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Basic Pharmacokinetics
Author: Mohsen A. Hedaya
Publisher: CRC Press
Release Date: 2007-04-23
Pages: 328
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.

Basic Pharmacokinetics  Second Edition
Author: Mohsen A. Hedaya
Publisher: CRC Press
Release Date: 2012-02-09
Pages: 595
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Essentials Of Biopharmaceutics And Pharmacokinetics   E Book
Author: Ashutosh Kar
Publisher: Elsevier Health Sciences
Release Date: 2010-09-15
Pages: 368
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.

Basic Pharmacokinetics And Pharmacodynamics
Author: Sara E. Rosenbaum
Publisher: John Wiley & Sons
Release Date: 2016-12-27
Pages: 576
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Basic Pharmacokinetics
Author: Sunil Jambhekar
Publisher:
Release Date: 2009
Pages: 407
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This is an essential guide to the study of absorption, distribution, metabolism and elimination of drugs in the body.

Essentials Of Pharmacokinetics And Pharmacodynamics
Author: Thomas N. Tozer
Publisher: LWW
Release Date: 2015-09-01
Pages: 408
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

A Comprehensive Guide To Toxicology In Nonclinical Drug Development
Author: Ali S. Faqi
Publisher: Academic Press
Release Date: 2016-11-03
Pages: 986
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Essential Thrombocythemia  New Insights For The Healthcare Professional  2013 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2013-07-22
Pages: 32
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Essential Thrombocythemia: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Additional Research in a compact format. The editors have built Essential Thrombocythemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Essential Thrombocythemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook Of Essential Psychopharmacology
Author: Ronald W. Pies
Publisher: American Psychiatric Pub
Release Date: 2007-04-02
Pages: 556
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Handbook of Essential Psychopharmacology, Second Edition, provides an indispensable guide to vital information in the rapidly expanding field of psychopharmacology. The updated edition of this popular handbook will continue to be a reference that is simply the essential starting point in psychopharmacology for residents and experienced clinicians alike. Busy residents and clinicians will find a quick, current, and accessible guide to basic facts about psychotropic drugs, including dosages, indications, and drug interactions. As in the first edition, its structure is clear and easy to read, including An all-new introductory chapter, designed to equip the reader with a basic understanding of pharmacodynamics and pharmacokinetics Four main chapters covering the four main groups of psychotropic medications: antidepressants, antipsychotics, anxiolytics, and mood stabilizers A consistent format for all four chapters that summarizes critical information about each group of medications, including drug class, indications, mechanisms of action, pharmacokinetics, main side effects, drug-drug interaction, potentiating maneuvers, and use in special populations A wealth of tables and graphs for quick clinical consultation and unique self-instruction sets of questions and answers Fascinating and educational vignettes and puzzlers, extensive references for further reading, and -- new to this edition -- an invaluable appendix of fifty questions and answers, designed to test the reader's knowledge and comprehension of the text Densely informative and packed with practical material and special features, this truly essential guide is a handy clinical reference for experienced clinicians, an ideal teaching tool for educators, and a useful resource for residents, especially those preparing for the psychiatry board examinations.

Kidney In Essential Hypertension
Author: Franz H. Messerli
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 260
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The kidney, similar to the heart, plays a three-fold role in essential hypertension. First, it participates in the patho genesis of arterial hypertension. Second, it suffers as a target organ of long-standing hypertension, and third, it experiences the effects of antihypertensive therapy. Perhaps most contested at the present time is the involvement of the kidney in the patho genesis of essential hypertension. More than a century ago, William Osler put forward three basic hypotheses about the "genuine contracted kidney. "l 1. "The hypertrophy can be regarded as an effect to overcome a sort of stop-cock action of the vessels when under the influence of an irritating ingredient in the blood greatly contracted and increased the peripheral resistance. " Clearly this hypothesis of an "irritating ingredient" is perhaps the most convincing nowadays, and numerous attempts have been made to identify a specific vasoconstrictive agent in the blood in essential hypertension. 2. "The obliteration of a large number of capillary territories in the kidney materially raised the arterial pressure. An additional factor of dimin ished excretion of water also heightened the pressure within the blood vessel. " Today we know that fluid volume overload in the presence of reduced renal mass seems to be the most likely mechanism accoun ting for renal parenchymal hypertension and, as shown by Guyton's group, for certain forms of experimental hypertension. 3.

Pharmacology   Pharmacokinetics
Author: Mark Tomlin
Publisher: Springer Science & Business Media
Release Date: 2010-07-30
Pages: 86
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Effective drug administration is a crucial skill for any practitioner working in the critical care unit. This book, in providing a concise account of the fundamental principles of pharmacology and pharmacokinetics, equips the critical care physician for such a task. In addition to the principles of pharmacology and pharmacokinetics, this volume alerts the reader to factors that affect drug action such as disease, pregnancy and age, and advises on how to adjust drug dosages accordingly. The specialist therapeutics covered comprise drugs targeting the gastro-intestinal tract, sedation, non-opioid analgesia and opiates. A quick and easy reference, this volume will prove a valuable asset for both trainees and fully qualified practitioners in critical care.

Applied Biopharmaceutics And Pharmacokinetics
Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
Release Date: 1993
Pages: 625
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Applied Biopharmaceutics   Pharmacokinetics
Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
Release Date: 1999
Pages: 768
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This new edition emphasizes the application and understanding of basic theoretical principles of biopharmaceutics and pharmacokinetics. Now with a second highlight color, this book helps students gain skills in problem solving and includes examples and practice problems and solutions.

Essential Hypertension 2
Author: Kyuzo Aoki
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 404
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The First International Symposium on Mechanism and Treatment in Essential Hypertension was held on October 23 and 24, 1985 in Nagoya. The Second International Symposium, which was held on May 30,31, and June 1, 1988 in Nagoya, was a success thanks to the endeavors of all the participants. These symposiums were made possible by the generous support of the city of Nagoya, Aichi Prefec ture, and various contributions. Understanding of the mechanisms of gene (major gene, essential) hypertension is impossible unless we comprehend the physiological properties of arterial smooth muscle. Since Langendorff's discovery of the role of calcium ions in muscle contraction in 1895, we have made immense progress in our knowledge of the role of the calcium ion in the excitation-contraction coupling of the arterial smooth mus cle. Investigation of the molecular mechanisms controlling the cellu lar basis of calcium ion action has been established with the discovery of the calcium binding protein (Ebashi 1963). The participation of the calcium induced calcium mechanism in the contraction of muscle has been directly demonstrated by using chemically skinned smooth muscle fibers (Endo et al. 1977). Methods for intracellular free cal cium contents and calcium channel activity have been developed and contribute to the study of the role of the calcium ion in arterial smooth muscle contractility. Such recent progress promotes study of the basic physiological, biochemical, and molecular properties of the calcium channel, and, in the field of hypertension research, the sodium and potassium channels.

Herbs And Natural Supplements Inkling
Author: Lesley Braun
Publisher: Elsevier Health Sciences
Release Date: 2010-06-24
Pages: 900
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A must-have health companion for herbalists, naturopaths, complementary medicine practitioners and students Herbs and Natural Supplements, 3rd Edition: An evidence-based guide presents evidence-based information on the 130 most popular herbs, nutrients and food supplements used across Australia and New Zealand. This exhaustive textbook is organised alphabetically by each herb or nutrient’s common name. Herbs and nutrients are then accompanied by critical information such as daily intake, main actions and indications, adverse reactions, contraindications and precautions, safety in pregnancy and more. This new edition of Herbs and Natural Supplements has been expanded with new chapters on pregnancy and wellness. It also features 10 new monographs for Arginine, Dunaliella, Elde, Goji, Pelargonium, Prebiotics, Red Yeast Rice, Rhodioloa, Shatavari and Taurine. • provides current, evidence-based information on herbal, nutritional and food supplements used in Australia and New Zealand • is user-friendly and easily organised by easy-to-find A-Z herbal monographs • appendices offering important additional information for the safe use of herbal and nutritional supplements, including a list of poison information centres, associations, manufacturers and more • offers clear, comprehensive tables including herb/natural supplement - drug interactions • lists the pharmacological actions of all herbs and natural supplements • a glossary of terms relevant to herbs and natural supplements • two comprehensive new chapters: Herbs and Natural Supplements in Pregnancy and Introduction to Wellness • all chapters completely updated and expanded • ten new monographs taking the total to 130 • now also available as an eBook! A code inside Herbs and Natural Supplements, 3rd Edition: An evidence-based guide enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material

Pharmacokinetics
Author: Philip Rowe
Publisher: Bookboon
Release Date: 2012
Pages: 147
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"All the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered. The essential mathematical basis of PKs is explained, but excessive mathematical complexity is avoided. For all key equations, practical examples of their use are provided. There are plenty of practice questions (along with model answers). Additional spreadsheets are provided on the net"-- provided by publisher.

Mass Spectrometry In Drug Metabolism And Pharmacokinetics
Author: Ragu Ramanathan
Publisher: John Wiley & Sons
Release Date: 2011-09-20
Pages: 390
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Modeling In Biopharmaceutics  Pharmacokinetics And Pharmacodynamics
Author: Panos Macheras
Publisher: Springer
Release Date: 2016-03-30
Pages: 483
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)