early vascular aging

Early Vascular Aging  EVA
Author: Peter M Nilsson
Publisher: Academic Press
Release Date: 2015-08-06
Pages: 376
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

ASSOCIATION OF CARDIOVASCULAR RISK FACTORS AND EARLY VASCULAR AGEING IN TYROLEAN ADOLESCENTS   EVA TYROL STUDY
Author:
Publisher:
Release Date: 2017
Pages:
ISBN:
Available Language: English, Spanish, And French
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BACKGROUND AND AIM Atherosclerosis is the most common cause of cardiovascular disease (CVD) and has its origin early in life. The prevalence of classic CVD risk factors like smoking, overweight, hypertension and unfavorable blood lipids in childhood and adolescence is associated with an increased risk for CVD in adulthood. Therefore this study aims to assess vascular changes and predictors for early vascular ageing (EVA) in a large cohort of healthy Tyrolean adolescents.METHODS Volunteering Tyrolean schools and companies were invited to take part in this regional cohort study. Common risk factors for CVD like smoking, activity, and diet were assessed as well as anthropometric data (BMI, blood pressure) and blood lipids. Vascular changes were evaluated by measuring intima-media-thickness of the common carotid artery (cIMT) by high resolution ultrasound as a marker for subclinical atherosclerosis.RESULTS 1573 (691 male, 882 female) adolescents with a mean age of 16 years were included in this analysis. 1556 participants had ultrasound measurement of cIMT. In a multivariable linear regression analysis male sex, BMI, daily physical activity and systolic blood pressure showed a positive relation to mean cIMT. Maximum cIMT was predicted by sex, BMI and systolic blood pressure. CONCLUSION Risk factors for atherosclerosis are present in Tyrolean adolescents and are associated with early vascular aging. The positive association between physical activity and mean cIMT may be explained by a non-atherosclerotic adaptation process. Maximum cIMT as a marker for first atherosclerotic lesions is not affected by physical activity.

Vascular Aging  Facts And Factors
Author: Elisabet Vila
Publisher: Frontiers E-books
Release Date:
Pages:
ISBN:
Available Language: English, Spanish, And French
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The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Blood Pressure And Arterial Wall Mechanics In Cardiovascular Diseases
Author: Michel E. Safar
Publisher: Springer
Release Date: 2014-07-30
Pages: 567
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a. –Basic concepts and pathophysiological mechanisms of PAHb. –Clinical aspects and end-organ damage in PAHc. – Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.​

Manual Of Hypertension Of The European Society Of Hypertension  Third Edition
Author: Giuseppe Mancia
Publisher: CRC Press
Release Date: 2019-06-06
Pages: 650
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Prehypertension And Cardiometabolic Syndrome
Author: Reuven Zimlichman
Publisher: Springer
Release Date: 2018-12-06
Pages: 689
ISBN:
Available Language: English, Spanish, And French
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This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines. While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation. In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.

Handbook Of Evidence Based Practice In Clinical Psychology  Child And Adolescent Disorders
Author: Michel Hersen
Publisher: John Wiley & Sons
Release Date: 2012-08-02
Pages: 752
ISBN:
Available Language: English, Spanish, And French
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Handbook of Evidence-Based Practice in Clinical Psychology, Volume 1 covers the evidence-based practices now identified for treating children and adolescents with a wide range of DSM disorders. Topics include fundamental issues, developmental disorders, behavior and habit disorders, anxiety and mood disorders, and eating disorders. Each chapter provides a comprehensive review of the evidence-based practice literature for each disorder and then covers several different treatment types for clinical implementation. Edited by the renowned Peter Sturmey and Michel Hersen and featuring contributions from experts in the field, this reference is ideal for academics, researchers, and libraries.

Advances In Hypertension Research And Treatment  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 27
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances in Hypertension Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Hypertension in a compact format. The editors have built Advances in Hypertension Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hypertension in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Hypertension Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Influence Of Hormones On Lipid Metabolism In Relation To Arteriosclerosis
Author: Abraham Dury
Publisher:
Release Date: 1959
Pages: 268
ISBN:
Available Language: English, Spanish, And French
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SIRT1 In Endothelial Cells As A Novel Target For The Prevention Of Early Vascular Aging
Author:
Publisher:
Release Date: 2016
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Abstract : Abstract: As one of the main risk factors for cardiovascular diseases, ageing plays an important role in the alterations of vascular structure and function. Early vascular ageing refers to a condition in patients with impaired endothelial function and increased arterial stiffness that can be assessed before the overt clinical manifestations, such as hypertension and atherosclerosis. Both epidemiological and experimental data indicate that the biological age of endothelial cells in patients with cardiovascular diseases is older than their chronological age. In fact, endothelial senescence is present at the early stage of vascular ageing and contributes to the development of endothelial dysfunction and arterial stiffness. Sirtuin 1 (SIRT1), the mammalian ortholog of yeast longevity regulator Sir2, is a nicotinamide adenine dinucleotide (NAD + )-dependent protein deacetylase that elicits a variety of vasoprotective functions. Overexpression of SIRT1 in endothelium prevents cellular senescence, enhances vasodilatory responses, and attenuates ageing-induced vascular damages. The present review summarizes the recent progresses related to SIRT1-mediated beneficial effects on the prevention of early vascular ageing and discusses the potential of SIRT1 in endothelial cells as an antivascular ageing target.

A Comprehensive Guide To Geriatric Rehabilitation
Author: Timothy L. Kauffman
Publisher: Elsevier Health Sciences
Release Date: 2014-09-05
Pages: 528
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Now in its third edition, this trusted clinical guide enables both the busy practitioner and student to review or to learn about a range of pathologies, conditions, examinations, diagnostic procedures, and interventions that can be effectively used in the physical rehabilitation of older people. It presents a broad overview of age-related physiological changes as well as specific professional discipline perspectives. Organized into eleven distinct and interrelated units, the first unit begins with key anatomical and physiological considerations seen with aging which have significant impact on the older person. The second and third units go on to review important aging-related conditions and disorders of the musculoskeletal and neuromuscular/neurological systems respectively. Neoplasms commonly encountered in older people are the focus of the fourth unit; while aging-related conditions of the cardiovascular, pulmonary, integumentary and sensory systems are presented in units five through seven. Unit eight highlights a range of specific clinical problems and conditions commonly encountered with older patients. Critically, all of these units emphasize important examination and diagnostic procedures needed for a thorough evaluation and stress interventions that can be of significant benefit to the older patient. The ninth unit presents select physical therapeutic interventions that are especially important in managing rehabilitative care. Key societal issues related to aging are discussed in the tenth unit. Finally, the concluding eleventh unit focuses on the successful rehabilitation team that includes both professional and non-professional caregiver members. A trusted guide to the conditions and problems faced when evaluating and treating geriatric patients Extensive coverage over 84 chapters, each written by an expert in the field Includes imaging, vision and the aging ear Cross-referenced - providing the complexity and inter-relatedness of co-morbidities common to aging patients Collaborative international perspective Chapters on the aging spine; frailty; safe pilates for bone health; health care for older people Additional renowned editor - Ronald W. Scott Revised title to reflect the comprehensive scope of content covered (previously entitled Geriatric Rehabilitation Manual)

Preventive Cardiology  A Companion To Braunwald S Heart Disease E Book
Author: Roger Blumenthal
Publisher: Elsevier Health Sciences
Release Date: 2011-02-25
Pages: 632
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Endorsed by the American Society for Preventive Cardiology! Preventive Cardiology - a new Companion to Braunwald’s Heart Disease - addresses the prevention and risk stratification of cardiovascular disease so that you can delay the onset of disease and moderate the effects and complications. Drs. Roger Blumenthal, JoAnne Foody, and Nathan Wong discuss the full range of relevant considerations, including the epidemiology of heart disease, risk assessment, risk factors, multiple risk factor-based prevention strategies, and developments in genetics and personalized medicine. This authoritative reference gives you the clinically relevant information you need for the effective prevention of cardiovascular disease. Recognize the factors for prevention and risk stratification around cardiovascular disease and effectively delay the onset of disease and moderate the effects and complications, even for individual who are genetically predisposed. Effectively navigate full range of considerations in prevention from epidemiology of heart disease, biology of atherosclerosis and myocardial infraction, risk assessment—established risk factors and emerging risk factors, multiple risk factor-based prevention strategies, and future directions—through genetics, personalized medicine, and much more. Tap into the expertise of prominent leaders in cardiovascular disease prevention with guidance from Drs. Roger Blumenthal—longtime director of the Framingham Heart Study—JoAnne Foody, and Nathan Wong. Gain a deeper understanding of the pathogenesis of disease and the rationale for management through discussions of basic science. Apply current clinical practice guidelines to ensure optimal outcomes in both primary and secondary prevention.

Hypertension  A Companion To Braunwald S Heart Disease E Book
Author: Henry R. Black
Publisher: Elsevier Health Sciences
Release Date: 2012-08-01
Pages: 608
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Effectively manage the chronic problems of your hypertensive patients with the practical clinical tools inside Hypertension, 2nd Edition: A Companion to Braunwald’s Heart Disease. This respected cardiology reference covers everything you need to know - from epidemiology and pathophysiology through diagnosis, risk stratification, treatment, outcome studies, concomitant diseases, special populations and special situations, and future treatments. Confidently meet the needs of special populations with chronic hypertensive disease, as well as hypertension and concomitant disease. Learn new methods of aggressive patient management and disease prevention to help ensure minimal risk of further cardiovascular problems. Benefit from the authors’ Clinical Pearls to reduce complications of hypertension. Use new combination drug therapies and other forms of treatment to their greatest advantage in the management of chronic complications of hypertension. Successfully employ behavior management as a vital part of the treatment plan for hypertensives and pre-hypertensives.

Mechanisms Of Cardiovascular Aging
Author: T. Hagen
Publisher: Elsevier Science Limited
Release Date: 2002-12-03
Pages: 403
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression. This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

The Biology Of Human Longevity
Author: Caleb E. Finch
Publisher: Elsevier
Release Date: 2010-07-28
Pages: 640
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

A Life Course Approach To Healthy Ageing
Author: Diana Kuh
Publisher: OUP Oxford
Release Date: 2013-12-19
Pages: 288
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Healthy ageing has long been a neglected area of epidemiological research as the traditional focus has been on specific chronic diseases of older life. There is a growing consensus from scientists, research funders and policy makers that ageing itself needs to be studied from an interdisciplinary and life course perspective, to inform strategies for reducing the societal and individual costs of an ageing population. A Life Course Approach to Healthy Ageing is a synthesis of life course perspectives in epidemiology and interdisciplinary perspectives in ageing research. It brings together expert investigators of maturing birth cohort and ageing studies, cross-cutting methodologists, and authorities in ageing research and knowledge transfer from across the world in one wide-ranging volume. Contributors discuss how aspects of healthy ageing are conceptualised, defined and measured; relate to each other; change across life; and are influenced by biological, psychological and social factors operating from early life onwards. They identify research gaps, and suggest how evidence from observational studies can be strengthened through improved study design and longitudinal analysis, thereby increasing the research contribution to practice or policy change. The book considers how we might delay or slow down the progressive, generalised impairment of function that occurs at the individual, body system and cellular levels, as people grow older. It also considers the determinants of wellbeing in older people, including personal fulfilment, positive emotions and social relationships. Broad in scope, discussing topics from genetics to psychological and social wellbeing, A Life Course Approach to Healthy Ageing is a key resource for epidemiologists, social scientists, clinicians, public health physicians, policy makers and practitioners with a research interest in healthy ageing.

The Effects Of Aging And Environment On Vision
Author: Donald Armstrong
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 231
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book derives from a symposium conducted in San Francisco CA, entitled "Environmental Design for Optimum Vision in the Elderly" that was sponsored by the American Aging Association, October 11-12, 1985. Presentations from this symposium comprise the core content of this volume. However, manuscripts have also been accepted from additional authors whose topics and research findings increase the scope and goals of this volume. Previously unpublished data is found in several of the chapters. In addition new data and references have been incorporated at the end of chapters in order to provide a current update of the subject. The broad aims of the papers in this volume were to examine the effects of various environmental factors, long-term occupational hazards, and toxins on basic visual functions in relation to physiological, biochemical, morphological, and pathological alterations in the eye and visual pathways, and centers of the brain. As part of the more specific aims of this volume, the editors have provided the following framework for the specific topics included in this volume: I) Epidemiology, Clinical and Psychophysical Research, II) Ophthalmological, Biochemical, Physiological and Anatomical studies, and III) Environmental Hazards.

Aging  Heart Disease  And Its Management
Author: Niloo M. Edwards
Publisher: Springer Science & Business Media
Release Date: 2002-11-14
Pages: 390
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Reviews the best therapies and surgical techniques available to provide quality care for the elderly cardiac patient and of those areas that require further research. The authors detail preventive therapies and the cardiovascular syndromes that disproportionately afflict the older individual, including arrhythmias (particularly atrial fibrillation), syncope, heart failure (particularly diastolic heart failure), and ischemic heart disease. They also delineate the surgical management of the heart patient with discussions of postoperative management and its complications and of specific surgical procedures such as coronary artery bypass grafting, valve surgery, pacemaker and defibibrillators, and surgical management of heart failure.

Cardiovascular Disease In The Elderly  Fourth Edition
Author: Wilbert S. Aronow
Publisher: CRC Press
Release Date: 2008-02-27
Pages: 865
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Physicians, gerontologists, cardiologists, and all clinicians caring for the elderly require a basic understanding of cardiovascular disease and disorders found in aging patients. This text has been updated to provide an in-depth overview of the epidemiology, pathophysiology, evaluation, and treatment of cardiovascular disorders in older adults.

Cardiovascular Disease In The Elderly  Third Edition  Revised And Expanded
Author: Wilbert S. Aronow
Publisher: CRC Press
Release Date: 2004-02-23
Pages: 1391
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Certain to become the most trusted source in geriatric cardiology, this Third Edition compiles the latest studies and expertise on the epidemiology, pathophysiology, and management of cardiovascular disease in the elderly patient, tracking the rapid pace of innovation in the field with in-depth explorations of the most recent clinical trials and advances in vascular biology, cardiology, and cardiovascular surgery for influential developments in disease prevention and management.