discovery and development of antidiabetic agents from natural products

Discovery And Development Of Antidiabetic Agents From Natural Products
Author: Goutam Brahmachari
Publisher: Elsevier
Release Date: 2016-10-11
Pages: 332
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Discovery And Development Of Neuroprotective Agents From Natural Products
Author: Goutam Brahmachari
Publisher: Elsevier
Release Date: 2017-05-18
Pages: 490
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Drug Discovery From Nature
Author: S. Grabley
Publisher: Springer Science & Business Media
Release Date: 1998-11-26
Pages: 347
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Thermal Biosensors Bioactivity Bioaffinity
Author: P.K. Bhatia
Publisher: Springer Science & Business Media
Release Date: 1999
Pages: 238
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The immobilized biocatalyst (IMB) is a key component of biotransformation systems that are used to transform substrates to desired products. The impro- ment of biocatalyst properties has a direct influence on the overall effectiveness of the process based on the biotransformation. The basic catalytic characte- stics of biocatalyst that are followed include kinetic properties, pH optima, stability, and inhibition. The investigation of catalytic properties of immobilized enzymes is still a time consuming procedure and is not always simple. In the 1980s, a major effort was made to standardize the rules by which IMB is char- terized. The Working Party of EFB on immobilized biocatalysts has formul- ed principles of individual methods, among them the requirement of kinetic characterization [1]. It was recommended to use a packed-bed reactor, equipped with temperature control and with infinite flow circulation. The system should be equipped with a post-column unit to measure the time-dependence of the product or substrate concentration [2, 3], the most commonly used analytical methods being spectrophotometry, chemiluminiscence, automatic titration, bioluminiscence, chromatography, polarimetry, and biosensors based on the oxygen electrode. There are two main drawbacks to the application of these methods: 1. The need to vary the analytical principles, depending on the chemical and physical-chemical properties of analytes; 2. In some cases, mainly in the study of hydrolytic enzymes, the natural s- strate must be replaced by an artificial one, that is chromolytic, chromogenic, chemiluminiscent, bioluminiscent, or fluorescent.

Studies In Natural Products Chemistry
Author: Suresh R. Naik
Publisher: Elsevier Inc. Chapters
Release Date: 2013-03-15
Pages: 504
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Bioactive natural products are an excellent source of novel therapeutics. The search for bioactive molecules from nature continues to play a major role in developing new generation natural products of therapeutic importance. The present critical review includes research work carried out by active researchers in natural products’ chemistry, pharmacology and therapeutics, and their implications in antidiabetic medications. This compiled scientific information will be a useful resource for future research especially in indentifying promising leads and direction for the development of novel drugs including useful adjuvants for the treatment of diabetic patient. The present therapeutic approaches in the treatment of diabetes are mainly focused to lower the elevated blood glucose by reducing its absorption in gastrointestinal tract, enhancing the sensitivity of insulin, controlling or modulating hepatic glucose output, and increased utilization of the glucose by the peripheral tissues. Involvement of oxidative stress and its impact on the cellular damage in diabetes mellitus has been established and could be a useful paradigm for the development of novel antihyperglycemics along with other therapeutic strategies. The present review also highlights the effects of various herbs, phytoconstituents, phytochemicals, microbial metabolites, and products of marine origins on hyperglycemic/diabetic conditions. Furthermore, efforts were made to discuss novel molecular targets such as insulin-signaling pathways, peroxisome proliferative activating receptor-γ, and G-protein-coupled receptors that are participating in enhancing/influencing insulin secretion, critical carbohydrate metabolism pathways, endoplasmic reticulum stress-related pathways, intracellular events associated intracellular inflammation, and chromatin-modification pathways involvement in antidiabetic activity and their significance.

Natural Products
Author: Lixin Zhang
Publisher: Springer Science & Business Media
Release Date: 2007-11-17
Pages: 386
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Environmental Health Perspectives
Author:
Publisher:
Release Date: 1993
Pages:
ISBN:
Available Language: English, Spanish, And French
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Drug Discovery Handbook
Author: Shayne C. Gad
Publisher: Wiley-Interscience
Release Date: 2005-07-11
Pages: 1471
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Index Of Conference Proceedings Received
Author: British Library. Document Supply Centre
Publisher:
Release Date: 1986
Pages:
ISBN:
Available Language: English, Spanish, And French
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Chemistry Of The Amazon
Author: International Symposium on Chemistry and the Amazon
Publisher: Amer Chemical Society
Release Date: 1995
Pages: 315
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Agroforest strategies for alleviating soil chemical constraints to food and fiber production in the Brazilian Amazon.

Two Centuries Of American Medicine  1776 1976
Author: James Bordley
Publisher: W B Saunders Company
Release Date: 1976
Pages: 844
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Chronicles advances in medical education and the prevention and treatment of disease in the two hundred years since America's independence

Pharmacology And Therapeutics For Dentistry   E Book
Author: John A. Yagiela
Publisher: Elsevier Health Sciences
Release Date: 2010-03-19
Pages: 960
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Pharmacology
Author: Ruth R. Levine
Publisher:
Release Date: 1978
Pages: 513
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Search
Author:
Publisher:
Release Date: 1974
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Chemistry Towards Disease And Poverty Eradication
Author:
Publisher:
Release Date: 2005
Pages: 365
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The Journal Of Environment   Development
Author:
Publisher:
Release Date: 2001
Pages:
ISBN:
Available Language: English, Spanish, And French
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Ethnobotany And The Search For New Drugs
Author: CIBA Foundation Symposium
Publisher: Wiley
Release Date: 1994-12-20
Pages: 290
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.

Natural Products And Drug Development
Author: Povl Krogsgaard-Larsen
Publisher: Raven Press
Release Date: 1984
Pages: 559
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume presents a survey of the development of bioactive compounds from natural sources. Major areas covered include terrestrial and marine sources for active constituents and lead structures; natural products as experimental tools and leads in drug design; antimicrobial and antitumor compounds; and natural products in drug development.

Science   Culture
Author:
Publisher:
Release Date: 2002
Pages:
ISBN:
Available Language: English, Spanish, And French
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Journal Of The Franklin Institute
Author: Franklin Institute (Philadelphia, Pa.)
Publisher:
Release Date: 1826
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Vols. 1-69 include more or less complete patent reports of the U.S. Patent Office for years 1825-59. Cf. Index to v. 1-120 of the Journal, p. [415].