developing therapeutics for alzheimers disease

Developing Therapeutics For Alzheimer S Disease
Author: Michael S. Wolfe
Publisher: Academic Press
Release Date: 2016-05-27
Pages: 676
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

BACE
Author: Varghese John
Publisher: John Wiley & Sons
Release Date: 2010-03-05
Pages: 272
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

Alzheimer S Disease
Author: Renee D. Wegrzyn
Publisher: CRC Press
Release Date: 2012-04-26
Pages: 298
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Emerging Drugs And Targets For Alzheimer S Disease  Neuronal Plasticity  Neuronal Protection And Other Miscellaneous Strategies
Author: Ana Martinez
Publisher: Royal Society of Chemistry
Release Date: 2010
Pages: 301
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Drug Discovery And Development For Alzheimer S Disease  2000
Author: Howard M. Fillit, MD
Publisher: Springer Publishing Company
Release Date: 2002-01-03
Pages: 296
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Pharmacological Mechanisms In Alzheimer S Therapeutics
Author: A. Claudio Cuello
Publisher: Springer Science & Business Media
Release Date: 2007-12-22
Pages: 324
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.

Neurobiology Of Alzheimer S Disease
Author: David Dawbarn
Publisher: Oxford University Press, USA
Release Date: 2007
Pages: 468
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Current State Of Alzheimer S Disease Research And Therapeutics
Author: Mary Lou Michaelis
Publisher: Academic Press
Release Date: 2012
Pages: 383
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Frontiers In Clinical Drug Research   Alzheimer Disorders  Volume 7
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2018-11-02
Pages: 276
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders.

Emerging Drugs And Targets For Alzheimer S Disease  Beta Amyloid  Tau Protein And Glucose Metabolism
Author: Ana Martínez
Publisher: Royal Society of Chemistry
Release Date: 2010
Pages: 317
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Central Nervous System Diseases  New Insights For The Healthcare Professional  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 205
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Central Nervous System Diseases. The editors have built Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Alzheimer Disease
Author: Robert Becker
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 614
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Dementia  4th Edition
Author: David Ames
Publisher: CRC Press
Release Date: 2010-11-26
Pages: 824
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.

Alzheimer S Disease   Modernizing Concept  Biological Diagnosis And Therapy
Author: M.C. Carrillo
Publisher: Karger Medical and Scientific Publishers
Release Date: 2012-04-23
Pages: 200
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Alzheimers Disease
Author: Margaret Strock
Publisher: DIANE Publishing
Release Date: 1996-03
Pages: 34
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Covers: what is Alzheimer's; the diagnosis of Alzheimer's Disease; the search for the cause of Alzheimer's Disease; the treatment of Alzheimer's Disease; and hope for the future through research. Glossary, references, and sources of help. Illustrated. Also includes a 28-page guide, "Early Identification of Alzheimer's Disease and Related Dementias."

Alzheimer S Disease
Author: Khalid Iqbal
Publisher: John Wiley & Sons
Release Date: 2003-01-24
Pages: 888
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

The Art Of Business
Author: Emery H. Mikel
Publisher: Jessica Kingsley Publishers
Release Date: 2013-04-28
Pages: 200
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Working as an independent contractor or in private practice is often the ideal scenario for creative therapists who want to control their own career and make decisions about the jobs and clients they take on. This practical guide to successful self-employment takes you through every step of the process, from coming up with the idea and marketing yourself, finding jobs, and interviewing, to maintaining jobs and what happens when you or your client want to end the job. Each chapter is packed with practical information and illustrative stories from the author's extensive experience of setting up her own art therapy business, considering all the likely obstacles you may face, and covering topics such as ethics and interns. This accessible companion contains all the information a creative therapist who wants to find work as an independent contractor will need to get started. It will be suitable for any level of experience and all creative therapists, including art, music, drama and dance therapists.

Alzheimer S Disease
Author: Robert Becker
Publisher: CRC Press
Release Date: 1990-09-19
Pages: 300
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book examines the relevance of current research for the early diagnosis of Alzheimer disease. It uncovers the present lack of clinical utility in research methodologies such as neuroimaging, drug challenges, electroencephalographs studies, and brain biopsy.

Molecular Biology Of Alzheimer S Disease
Author: Christian Haass
Publisher: CRC Press
Release Date: 2003-09-02
Pages: 330
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Research Progress In Alzheimer S Disease And Dementia
Author: Miao-Kun Sun
Publisher: Nova Publishers
Release Date: 2007
Pages: 438
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.