clinical trial design challenges in mood disorders

Clinical Trial Design Challenges In Mood Disorders
Author: Mauricio Tohen
Publisher: Academic Press
Release Date: 2015-01-24
Pages: 192
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients. Summarizes common trial design problems and their solutions Encompasses funding, subject selection, regulatory issues and more Identifies best practices for definitive and generalizable results Includes traditional trial designs and novel analytic techniques Represents academia, industry, regulatory agencies, and advocacy groups

The Medical Basis Of Psychiatry
Author: S. Hossein Fatemi
Publisher: Springer
Release Date: 2016-03-17
Pages: 1064
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Four years have passed since the last edition (3rd) of this book was published. In the intervening years, several reviews of this book have provided highly encouraging remarks about the value of this book in transmitting information on classification and treatment of psychiatric disorders to the audience. We are proposing to revise all chapters with an eye on accuracy and ease of use, and this is an especially timely endeavor with the upcoming publication of the Diagnostic and Statistical Manual V. All the appropriate new information on biology, etiology, diagnosis and treatment of psychiatric disorders will be added to the current proposed edition. It is our goal to recruit the same authors (if possible) who contributed to the previous edition. While all chapters will be updated (see TOC), those marked by asterisks will be the most likely to undergo more revision. Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the fourth edition of this book. In this updated and expanded edition, the reader will be provided with the most contemporary information and literature supported by a close survey of the field. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.

Diversity Issues In The Diagnosis  Treatment  And Research Of Mood Disorders
Author: Sana Loue
Publisher: Oxford University Press
Release Date: 2008
Pages: 307
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Mood disorders, like depression, bipolar disorder, and dysthymia, are common psychological illnesses that occur worldwide and across the life-span. There is a growing consensus among mental health clinicians and researchers that culture and cultural contect are often key determinants in mood disorder prevention and outcome. It have become increasingly apparent that an appropriate understanding of culture is essential for treatments to be effective, and for optimal outcomes to be obtained by individuals suffering from these conditions. This text focuses on cross-cultural issues arising in the context of diagnosis, treatment, and research of mood disorders within diverse populations of the United States. With specific case examples to supplement the topics reviewed in each chapter, this important volume will be of great interest to all clinicians and researchers working in the area of mood disorders.

Clinical Trials In Older Adults
Author: Antonio Cherubini
Publisher: John Wiley & Sons
Release Date: 2016-01-13
Pages: 280
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Clinical Trials in Older Adults is the first book to consider the methodological issues underlying the evaluation of new treatments in older people. Provides information on the methodology, monitoring and regulations for those planning to conduct a clinical trials involving older adults Contains examples of ongoing trials involving older adults, and presents the main characteristics of many recently published Depicts how the issues regarding older adults in clinical trials could be properly addressed with the appropriate study design and conduct Identifies key issues in performing clinical trials in older patients with common geriatric conditions, i.e. Alzheimer’s dementia, depression, low muscle mass, cancer

Bipolar Disorders
Author: Andreas Marneros
Publisher: Cambridge University Press
Release Date: 2005-10-06
Pages: 395
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book examines the full range of atypical, rapid cycling and transient forms of bipolar disorder.

Clinical Guide To Depression And Bipolar Disorder
Author: Martin B. Keller
Publisher: American Psychiatric Pub
Release Date: 2013-04-10
Pages: 234
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Conceived in the early 1970s to study the phenomenology, diagnosis, genetics, and clinical course of depression, the NIMH Collaborative Depression Study (CDS) has influenced research and practice since its inception. Clinical Guide to Depression and Bipolar Disorder: Findings From the Collaborative Depression Study summarizes key findings from the study and the related literature to provide comprehensive and up-to-date knowledge on the course and outcome of illness in mood disorders. Nowhere else can clinicians find such detailed longitudinal data, combined with astute clinical analysis of the current research. The volume offers: Historical background on how psychodynamic psychiatry was overtaken by psychobiological perspectives, and the challenges and controversies that gave rise to the CDS, providing the context necessary to understand the profession's development to the present day. A wealth of information on nosology, natural history, phenomenology, and treatment response in depressive and bipolar disorders. Detailed descriptions of the study methods employed, providing information and insights that will assist researchers in the longitudinal design of prospective cohort studies. Comprehensive review of outcomes in mood disorder, including delineation of the long-term course of bipolar I, bipolar II, and unipolar major depressive disorders, the implications of which will continue to be instrumental in the development of psychiatric nosology and indispensable to clinicians engaged in assessment and treatment. Critical information clinicians need in order to read the clinical signs in their patients and predict the "switch" from unipolar to bipolar disorder. A fascinating review of the evolution of diagnostic thinking about the role of anxiety in mood disorders, and the contributions of the CDS to the newly published DSM-5®. Each chapter is accompanied by a time-saving summary, as well as a section on clinical implications that translates the findings into practical points and key recommendations clinicians need to know to provide optimal care. Psychiatrists, clinical psychologists, residents, and fellows will turn to Clinical Guide to Depression and Bipolar Disorder: Findings From the Collaborative Depression Study to better understand the course and outcome of their patients' mood disorders and, ultimately, to improve their clinical skills.

Issues In Clinical Psychology  Psychiatry  And Counseling  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 2915
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Clinical Psychology, Psychiatry, and Counseling. The editors have built Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Psychology, Psychiatry, and Counseling in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bipolar Depression  Molecular Neurobiology  Clinical Diagnosis And Pharmacotherapy
Author: Carlos A. Zarate Jr.
Publisher: Springer Science & Business Media
Release Date: 2009-04-16
Pages: 279
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.

Communicating Nursing Research
Author:
Publisher:
Release Date: 1968
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Consists of papers presented at a conference sponsored 1968-73 by the Western Council on Higher Education for Nursing; 1974- by the Western Society for Research in Nursing; issues for 1993- contain also addresses and abstracts of the WIN Assembly.

Clinical Handbook For The Management Of Mood Disorders
Author: J. John Mann
Publisher: Cambridge University Press
Release Date: 2013-05-09
Pages: 426
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Provides a one-stop evidence-based guide to the management of all types of mood disorders.

Mood Disorders Across The Life Span
Author: Kenneth I. Shulman
Publisher: Wiley-Liss
Release Date: 1996-06-29
Pages: 442
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Mood Disorders Across the Lifespan provides a longitudinal perspective on age-associated variations in clinical presentation and treatment of bipolar disorder.

Next Generation Antidepressants
Author: Chad E. Beyer
Publisher: Cambridge University Press
Release Date: 2010-05-20
Pages: 137
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.

Issues In Pharmacology  Pharmacy  Drug Research  And Drug Innovation  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 4229
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Mental Health Research And Practice  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 804
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Mental Health Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mental Health Research and Practice. The editors have built Issues in Mental Health Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mental Health Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Mental Health Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

How To Write A Successful Research Grant Application
Author: Chief Prevention and Translational Research Program Division of Mental Disorders Behavioral Research and AIDS Willo Pequegnat
Publisher: Springer Science & Business Media
Release Date: 1995
Pages: 252
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This indispensable guide provides step-by-step assistance to researchers applying for biobehavioral and psychosocial research funding from the Public Health Service. The first section examines grantsmanship and the review process. Chapters explore the process for determining research opportunities and priorities and how scientific merit is established for research applications. The second section offers a step-by-step guide to completing the PHS 398 research application and includes examples. Chapters offer insights into developing a theoretical framework and writing testable hyptheses and much more.

Current Issues In Clinical Psychology
Author: Gill Edwards
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Pages: 256
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Since 1980, clinical psychologists and other professionals have gathered in Merseyside each year for the "Annual Merseyside Course in Clinical Psychology". The aim of this annual event is to offer post qualification training and a forum for discussion in areas of current clinical interest. Over the years, the course has attracted national and international speakers and attenders of the highest calibre, plus up-to-the-minute reports on current research. In August 1984, the course was held, for the first time, in the beautiful old city of Chester. As always, the papers were presented by leading clinicians and researchers in their respective fields; once again, this included several contributions from Merseyside psychologists. Since 1981, the proceedings of this conference have been published as "Current Issues in Clinical Psychology". The present volume - Volume 4 - covers four major areas of current interest: The Child and Therapy; Rehabilitation Across the Specialties; New Directions for Psychology and the Law; and Addictive Behaviors. Each of these areas must be relevant to the work of almost all clinical psychologists, at various times. The volume closely reflects the order and content of papers presented at the 1984 conference, although it also includes one paper (by Guliz Elal-Lawrence) written specially for this publication. The 1984 conference was widely acknowledged to be another succes- both academically and socially - and I hope that this volume fully conveys the interesting and stimulating ideas and information enjoyed by those who attended.

Issues In Proteins And Peptides Research And Application  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 1110
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Proteins and Peptides Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Proteins and Peptides Research and Application. The editors have built Issues in Proteins and Peptides Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proteins and Peptides Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Proteins and Peptides Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bipolar Disorder
Author: Lakshmi N. Yatham
Publisher: John Wiley & Sons
Release Date: 2011-06-28
Pages: 522
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant co-morbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is clinically relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have assembled a team of experts from around the world: in many instances, chapters are co-authored by people from different continents, bringing a truly international perspective to this important topic. The book covers the basic science of the pathology underlying bipolar disorder but addresses the clinical aspects of the disease throughout. The book comprises four sections: Descriptive Aspects—issues ranging from how the concept of bipolar disorder has evolved over the years to new information about neurocognitive impairment, creativity and economic productivity, and to discussion of the deliberations of the DSM-V committee on changes in diagnostic categories and criteria. Biology—the contribution of genes to this disorder, changes in circadian rhythms, what we know about brain changes and the role of oxidative stress. Biological Treatment and Psychosocial Treatment— all the latest information about pharmacological and psychological treatments and the optimal management of this condition. If you want to provide state-of-the-art care to your bipolar patients, be sure to consult this authoritative reference.

Issues In Neuroscience Research And Application  2011 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2012-01-09
Pages: 3141
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Wiley Encyclopedia Of Clinical Trials
Author: Lisa Marie Sullivan
Publisher: Wiley-Interscience
Release Date: 2008
Pages: 1374
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Here you'll find more than 500 entries from the world's leading experts in the field on the basic concepts, methodologies, and applications in clinical trials. The range of topics includes: basic statistical concepts, design and analysis of clinical trials, ethics, regulatory issues, and methodologies for clinical data management and analysis