carbonic anhydrases as biocatalysts

Carbonic Anhydrases As Biocatalysts
Author: Claudiu T Supuran
Publisher: Elsevier
Release Date: 2015-01-14
Pages: 398
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases
Author: Claudiu Supuran
Publisher: Academic Press
Release Date: 2019-07-17
Pages: 560
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Carbonic Anhydrases And Metabolism
Author: Claudiu T. Supuran
Publisher: MDPI
Release Date: 2019-04-08
Pages: 184
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publisher: CRC Press
Release Date: 2019-06-27
Pages: 774
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Biocatalysis
Author: D.A. Abramowicz
Publisher: Springer Science & Business Media
Release Date: 2013-03-09
Pages: 400
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The action of enzymes fascinated mankind long before they were rec ognized for the complex chemicals that they are. The first application of these remarkable compounds to produce ethanol by fermentation is lost to antiquity. Payer and Persoz (Ann. Chim. Phys. , 53, 73 (1833ii)) appear to have provided the first step toward understanding this com plex area when they reported the isolation of diastase in 1833. These workers showed that diastase could catalyze the hydrolysis of starches to sugars. Somewhat earlier Kirchhoff (Schwigger's Journal, 4, 108 (1812)) had shown that a small amount of dilute acid could hydrolyze a seemingly endless amount of starch to sugars. The genius of Berzelius recognized the commonality of these two observations in connection with a few other isolated observations and in 1834 coined the term catalysis to describe such actions. Professor Leibig was one of the giants of the chemical world in 1840. In addition to his own work, Liebig was training the world's next generation of chemists in his laboratory in Giessen. This cadre of chemists were very impressed by the master teacher so that is it only natural that Liebig's views should dominate with this next generation of chemists. Leibig was, in the 1830s and 1840s, developing his mastery of agricultural chemistry. The mechanism of putrefication was of great concern to Leibig, and he turned to the newly defined area of catalysis for an explanation.

Multi Scale Quantum Models For Biocatalysis
Author: Darrin M. York
Publisher: Springer Science & Business Media
Release Date: 2009-05-30
Pages: 420
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

“Multi-scale Quantum Models for Biocatalysis” explores various molecular modelling techniques and their applications in providing an understanding of the detailed mechanisms at play during biocatalysis in enzyme and ribozyme systems. These areas are reviewed by an international team of experts in theoretical, computational chemistry, and biophysics. This book presents detailed reviews concerning the development of various techniques, including ab initio molecular dynamics, density functional theory, combined QM/MM methods, solvation models, force field methods, and free-energy estimation techniques, as well as successful applications of multi-scale methods in the biocatalysis systems including several protein enzymes and ribozymes. This book is an excellent source of information for research professionals involved in computational chemistry and physics, material science, nanotechnology, rational drug design and molecular biology and for students exposed to these research areas.

Biochemistry Of Foods And The Biocatalysts
Author: Ishak I. Shahied
Publisher:
Release Date: 1977
Pages: 470
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The chemistry of foods; Water in foods; Lipids; Carbohydrates; Proteins; Flavonoids; Flavors in foods; Vegetables and fruits; Milk; Cereal chemistry; The chemistry of vitamins; Vitamin A; Vitamin D; Vitamin E; Vitamin K; Vitamin C; Thiamin (B1); Riboflavin (B2); Niacin; Pantothenic acid; Biotin; Pyridozine (B6); Vitamin B12; Folic acid; The chemistry of minerals; Minerals; Calcium; Phosphorus; Sodium; Potassium; Magnesium; The trace elements; Iron; Copper; Zinc; Manganese; Molybdenum; Cobalt; Selenium; Fluorine; Chromium; Physiology and biochemical reactioons of the hormones; Catecholamines; Hormones of the posterior pituitary; Hormones of the anterior pituitary; Adrenocorticotropic hormone (ACTH); Growth hormone (GH); Prolactin; Thyroid hormones; Parathyroid hormone; Insulin; Glucagon; Gonadotropic and sex hormones; Adrenal cortex hormones; Gastrointestinal hormones.

Applied Biocatalysis In Specialty Chemicals And Pharmaceuticals
Author: American Chemical Society Division Of Biochemical
Publisher: Amer Chemical Society
Release Date: 2001
Pages: 292
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Written for a wide variety of biotechnologists, this book provides a major review of the state-of-the-art in bioethanol production technologies, enzymatic biomass conversion, and biodiesel. It also provides a detailed explanation of a breakthrough in photosynthetic water splitting which could result in a doubling of the efficiency of solar energy conversion by green plants. The book covers production of lactic acid, succinic acid, 1,3-propanediol, 2,3-butanediol, and polyhydroxybutyrate and xylitol. It also includes a chapter on synthesis-gas fermentation.

Biocatalysis
Author:
Publisher:
Release Date: 1994
Pages:
ISBN:
Available Language: English, Spanish, And French
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Characterization And Application Of Biocatalysts In Extreme Environments
Author: Peter Christopher Michels
Publisher:
Release Date: 1996
Pages: 490
ISBN:
Available Language: English, Spanish, And French
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Technological Applications Of Biocatalysts
Author: Open Universiteit (Heerlen, Netherlands)
Publisher:
Release Date: 1993
Pages: 378
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book builds upon a knowledge of the properties of enzymes and shows how these important catalysts can be used in industry. The central theme demonstrates how proteins, especially enzymes and immunoglobins can be isolated, characterised and produced on a large scale. Specific examples are given and both practical and theoretical aspects are examined. Applications for a wide range of metabolites are described with particular emphasis on the design, performance and production of biosensors. * Step-by-step logical development * Student centered learning style * Texts planned by both industry and academia The need for a cost effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they are developing BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place. 'This is a particularly useful learning resource for people wanting to broaden their knowledge in biotechnology either informally or by extending their formal education in MScs and similar courses.' - Journal of Chemical Tech & Biotechnology, July 1995

Gas  Oil  Coal  And Environmental Biotechnology II
Author: Cavit Akin
Publisher: Inst of Gas Technology
Release Date: 1990
Pages: 587
ISBN:
Available Language: English, Spanish, And French
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Green Solvents For Organic Synthesis
Author: V. K. Ahluwalia
Publisher: Alpha Science International, Limited
Release Date: 2009
Pages: 346
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Solvents play an important role in organic synthesis. Most of the common organic solvents which have been used for organic synthesis include benzene, chloroform, toluene, carbon tetrachloride etc. Most of these are volatile (VOC) and have undesirable properties like toxicity or being harmful to the environment or may be obtained from non renewable petroleum sources. This book describes some of the most important green solvents, their merits and demerits. These green solvents include water, supercritical carbon dioxide, ionic liquids, polyethylene glycol and its solutions and the Florous Phase Technique. A large number of representative synthetic applications for each of the green solvents are described.

Carbon Dioxide Activation By Metal Complexes
Author: Arno Behr
Publisher: John Wiley & Sons
Release Date: 1988
Pages: 161
ISBN:
Available Language: English, Spanish, And French
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General  Organic  And Biochemistry
Author: William Henry Brown
Publisher: Brooks/Cole
Release Date: 1980
Pages: 734
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Studies With The Enzyme  Carbonic Anhydrase
Author: Harold Bernard Reisman
Publisher:
Release Date: 1959
Pages: 116
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Carbon Oxygen Lyases   Advances In Research And Application  2013 Edition
Author:
Publisher: ScholarlyEditions
Release Date: 2013-06-21
Pages: 97
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Carbon-Oxygen Lyases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Carbon-Oxygen Lyases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Carbon-Oxygen Lyases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

A Complete Course In ISC Biology
Author: V. B. Rastogi
Publisher: Pitambar Publishing
Release Date: 1997
Pages: 592
ISBN:
Available Language: English, Spanish, And French
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Ullmann S Biotechnology And Biochemical Engineering
Author: Wiley-VCH Staff
Publisher:
Release Date: 2007-08-03
Pages: 874
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The one-stop resource for all those involved in the biochemical and biotechnological industries. Based on the latest online edition of Ullmann's Encyclopedia of Industrial Chemistry containing articles never seen before in print, this ready reference meets the need for a detailed survey of the biochemical fundamentals and techniques as well as their applications in biochemical engineering and biobased production.

NEERI Annual Report
Author: National Environmental Engineering Research Institute
Publisher:
Release Date: 2006
Pages:
ISBN:
Available Language: English, Spanish, And French
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