brain lipids in synaptic function and neurological disease

Brain Lipids In Synaptic Function And Neurological Disease
Author: Jacques Fantini
Publisher: Academic Press
Release Date: 2015-05-12
Pages: 398
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. Written to provide a "hands-on" approach for readers Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings Step-by-step guide to memorize and draw lipid structures Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique

Research Awards Index
Author:
Publisher:
Release Date: 1984
Pages:
ISBN:
Available Language: English, Spanish, And French
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Diet And Exercise In Cognitive Function And Neurological Diseases
Author: Akhlaq A. Farooqui
Publisher: John Wiley & Sons
Release Date: 2015-02-05
Pages: 384
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Omega 3 Fatty Acids In Brain And Neurological Health
Author: Ronald Ross Watson
Publisher: Elsevier
Release Date: 2014-06-25
Pages: 496
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health. The first book-length collection of original research on the connection between omega-3 fatty acids and the brain Provides a comprehensive introduction to the state of research on omega-3 fatty acids and the brain and directions for future research A foundational collection for neuroscience, neurology, and nutrition research

Brain Lipids And Disorders In Biological Psychiatry
Author: E.R. Skinner
Publisher: Elsevier
Release Date: 2002-03-07
Pages: 173
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Leading authorities examine the possible role of brain lipids in the development of conditions such as schizophrenia, depression, Alzheimer's disease and personality disorders and violence. A better understanding of the underlying causes of these debilitating medical disorders is of utmost importance and may contribute towards a means of prevention, amelioration and cure. The book is intended to stimulate further interest and lead to increased research in this important development area.

Inflammation And Oxidative Stress In Neurological Disorders
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Release Date: 2014-01-27
Pages: 355
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Phytochemicals  Signal Transduction  And Neurological Disorders
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Release Date: 2012-07-10
Pages: 352
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Phytochemicals Signal Transduction and Neurological Disorders Phytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases. Unlike vitamins and minerals, phytochemicals are not required for sustaining cell viability, but they play an important role in protecting tissues and cells from the harmful effects of oxidative stress and inflammation. Examples of phytochemicals include catechins, resveratrol, ginkgo biloba, curcumin, and sulfur compounds found in garlic. Although, the precise molecular mechanisms associated with beneficial effects of phytochemicals still remain the subject of intense investigations, but it is becoming increasingly evident that phytochemicals mediate their effects by counteracting, reducing, and repairing the damage caused by oxidative stress and neuroinflammation. In addition, phytochemicals also stimulate the synthesis of adaptive enzymes and proteins through the stimulation of a transcription factor called Nrf2 and induction of phase II detoxifying enzymes. Consumption of phytochemicals induces neurohormetic response that results in the expression of adaptive stress-resistance genes that are responsible for encoding antioxidant enzymes, protein chaperones, and neurotrophic factor (BDNF). Based on the stimulation of signal transduction network and adaptive stress-resistance genes, it is proposed that the use of phytochemicals from childhood to old age along with regular exercise is an important strategy for maintaining normal aging and delaying onset of age-related neurological disorders (stroke, Alzheimer disease, and Parkinson disease). Phytochemicals Signal Transduction and Neurological Disorders presents readers with cutting edge and comprehensive information not only on bioavailability, and mechanism of action of phytochemicals in the brain, but also provides the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic (stroke, spinal cord trauma, and traumatic brain injury) and neurodegenerative (Alzheimers disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis) diseases.

Handbook Of The Biology Of Aging
Author: Caleb Finch
Publisher:
Release Date: 1977
Pages: 771
ISBN:
Available Language: English, Spanish, And French
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Lipid Mediators And Their Metabolism In The Brain
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Release Date: 2011-08-12
Pages: 327
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

Metabolic Syndrome
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Release Date: 2013-06-14
Pages: 412
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.

Movement Disorders  An Issue Of Neurologic Clinics
Author: Joseph Jankovic
Publisher: Elsevier Health Sciences
Release Date: 2014-12-27
Pages:
ISBN:
Available Language: English, Spanish, And French
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The daily life impact of movement disorders on people affected ranges from the inconvenient to major quality of life issues, depending upon the disorder and its progression. Topics in this issue of Neurologic Clinics address: Pathogenic Nechanisms of Neurodegeneration in Parkinson’s Disease; Treatment Strategies in Early and Advanced Parkinson’s Disease; Atypical Parkinsonism; Medical and Surgical Treatment of Tremors; Diagnosis and Treatment of Dystonia; Huntington’s Disease: Pathogenesis and Treatment; Tics and Tourette Syndrome; Paroxysmal Movement Disorders; Drug-induced Movement Disorders; Wilson Disease and other Neurodegenerations with Metal Accumulations; Psychogenic Movement Disorders; Ataxia; Gait Disorders; and Movement Disorders in Systemic Diseases. Videos are planned for the majority of the presentations and each article presents an Overview, Imaging, Pathology, and Diagnostic Dilemmas. The editor of this issue of Neurologic Clinics, Dr. Joseph Jankovic, is well known as expert in the pathophysiology, diganosis, and management of movement disorders - he has served as president of the international Movement Disorder Society and is recipient of numerous research awards related to these disorders. Dr Jankovic has involved world renown experts as authors in this publication.

The Handbooks Of Aging
Author: James E. Birren
Publisher:
Release Date: 1976
Pages:
ISBN:
Available Language: English, Spanish, And French
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Neurochemical Aspects Of Neurotraumatic And Neurodegenerative Diseases
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Release Date: 2010-09-02
Pages: 401
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Endocannabinoids And Lipid Mediators In Brain Functions
Author: Miriam Melis
Publisher: Springer
Release Date: 2017-07-03
Pages: 369
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The science of cannabinoids is 50 years old. These past years provided a remarkable and constant number of breakthroughs, showing that the signaling mediated by endocannabinoids and lipid mediators impacts almost every function of the body. Indeed, this represents a special field of research, which allows tackling the complexity of biological functions, and provides potential therapeutic frameworks for a plethora of diseases. The number of exciting discoveries brought up to the scientific community almost on a daily basis highlights the importance of an updated volume on this topic. Particularly, given that potential therapeutic benefits of cannabis and cannabinoids are currently under heavy analysis in many Countries worldwide. Hence, the main objective of this book is to explore not only some of the many functions of endocannabinoids (and lipid mediators) in physiological control of networks at a cellular and molecular level, but also to extend this knowledge for potential use of cannabinoids and/or drugs regulating endocannabinoid levels in vivo as therapeutic target(s) in neurological and neuropsychiatric disorders. In this book new findings and ideas about the endocannabinoid system and its roles as neuronal circuit modulator related to human brain pathologies characterized by alterations in neuroplasticity will be highlighted. Endocannabinoid roles in key systems controlling appetite, pain, learning and memory, as well as sleep and stress responses will be presented. In addition, pathological processes associated with changes in endocannabinoid signaling will be discussed in the context of anxiety, autism, depression and addiction. This book will provide an excellent background to researchers looking for extending their areas of interest, and to newcomers in the field.

The Psychoneuroimmunology Of Chronic Disease
Author: Kathleen Kendall-tackett
Publisher: Amer Psychological Assn
Release Date: 2010
Pages: 263
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Recent years have witnessed considerable growth in the field of psychoneuroimmunology (PNI), which describes how psychological factors, such as stress and depression, impact the neurological and immune systems. Research increasingly indicates that psychological states play a key role in the development and exacerbation of inflammatory diseases such as heart disease, diabetes, multiple sclerosis, Alzheimers, and autoimmune disorders. In this book, editor Kathleen Kendall-Tackett and an elite group of researchers explore the ways physical and psychological stressors such as poor sleep, PTSD, and depression, trigger the inflammatory response and increase the risk of disease. They approach this material from a variety of perspectives. Chapters in Part I describe the biological processes involved in inflammation, focusing on both the typical bodily response to threat as well as on the long-term deleterious effects of stress upon the immune system; while chapters in Part II examine the role of psychosocial stress in disease etiology. Throughout, chapter authors present evidence of connections between mind and body, and emphasize the need for improved communication between physicians and mental health care providers. This book will be a valuable resource for researchers as well as practitioners who hope to share the benefits of these findings with their clients.

Trace Amines And Neurological Disorders
Author: Tahira Farooqui
Publisher: Academic Press
Release Date: 2016-07-12
Pages: 432
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Molecular Biology Of The Cell
Author:
Publisher:
Release Date: 2000
Pages:
ISBN:
Available Language: English, Spanish, And French
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Pharmacology And Therapeutics For Dentistry   E Book
Author: John A. Yagiela
Publisher: Elsevier Health Sciences
Release Date: 2010-03-19
Pages: 960
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Diseases And Disorders In Infancy And Early Childhood
Author: Janette B. Benson
Publisher: Academic Press
Release Date: 2009-09-14
Pages: 424
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Currently, there are two types of pediatric disorder books available: high level technical books geared toward pediatric specialists, and self-help books for parents. The technical books cover diagnosis and treatment, while the self-help books cover general problems, are single authored, and speak little to the research of any given disorder. This volume consists of focused articles from the authoritative Encyclopedia of Infant and Early Childhood Development that cover the research information on common disorders in age 0-3. Topics include those most typically occurring, making them of great interest to both specialists and nonspecialists. Disorders and dysfunction of a variety of types are discussed, whether cognitive, social, emotional, or physiological. Coverage includes asthma, allergies, colic, bedwetting, diarrhea, genetic disorders, SIDS and learning disabilities, and provides an essential, affordable reference for researchers in developmental psychology, as well as allied health fields. Written at a level for general understanding—allows for easy and quick grasp of information to both specialists and non specialists alike Covers disorders across many systems (neurological, immunological etc) providing quicker access to info that would normally be dispersed across a wide literature Written by research experts ensuring accuracy that is sometimes lacking in non-specialist books Covers disorders, dysfunctions, and abnormal development in one place saving time looking at multiple sources for these related items

Scientific Approaches To Clinical Neurology
Author:
Publisher:
Release Date: 1977
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS: