basic principles of drug discovery and development

Basic Principles Of Drug Discovery And Development
Author: Benjamin Blass
Publisher: Elsevier
Release Date: 2015-04-24
Pages: 580
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

Basic Principles Of Drug Discovery And Development
Author: Benjamin E. Blass
Publisher: Academic Press
Release Date: 2020-11-01
Pages: 750
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, one that requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. This book bridges the knowledge gaps that invariably lead to communication issues, providing a fundamental understanding of the techniques and disciplines required for multifaceted drug research. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery process, from obtaining a lead, to testing bioactivity, to producing the drug and protecting intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery

Drug Discovery And Development
Author: H. P. Rang
Publisher: Churchill Livingstone
Release Date: 2006
Pages: 346
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Principles Of Anticancer Drug Development
Author: Elizabeth Garrett-Mayer
Publisher: Springer Science & Business Media
Release Date: 2010-12-29
Pages: 674
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Introduction To Biological And Small Molecule Drug Research And Development
Author: C. Robin Ganellin
Publisher: Academic Press
Release Date: 2013-05-07
Pages: 472
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Drug Discovery And Development  Volume 2
Author: Mukund S. Chorghade
Publisher: John Wiley & Sons
Release Date: 2007-02-16
Pages: 416
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Plant Bioactives And Drug Discovery
Author: Valdir Cechinel-Filho
Publisher: John Wiley & Sons
Release Date: 2012-05-22
Pages: 565
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

General And Molecular Pharmacology
Author: Francesco Clementi
Publisher: John Wiley & Sons
Release Date: 2015-07-01
Pages: 786
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

With a focus on functional relationships between drugs and theirtargets, this book covers basic and general pharmacology, from acellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis forproper clinical use- without neglecting clinical application,toxicology and pharmacokinetics. • Covers cell and molecular pharmacology,bringing together current research on regulation of drug targets,at a level appropriate for advanced undergrad and graduatestudents • Discusses the relevance ofpharmacokinetics and drug development for the clinical applicationof drugs • Presents material from the perspective ofdrug targets and interaction, the theoretical basis of drug actionanalysis, and drug properties • Focuses on structure-functionrelationships of drug targets – informing about theirbiochemical and physiologic functions and experimental and clinicalpathways for drug discovery and development • Has a companion website that offers ahost of resources: short additional chapters about methodology,topics at the forefront of research, all figures and tables fromthe book, and Power Point slides

Principles Of Clinical Pharmacology
Author: Arthur J. Atkinson, Jr.
Publisher: Elsevier
Release Date: 2011-04-28
Pages: 568
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry Expanded coverage of pharmacogenetics Expanded coverage of drug transporters and their role in interactions Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions A new chapter on drug discovery that focuses on oncologic agents Inclusion of therapeutic antibodies in chapter on biotechnology products

Principles Of CNS Drug Development
Author: John Kelly
Publisher: John Wiley & Sons
Release Date: 2009-10-27
Pages: 324
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery. Key Features: Discusses in detail the key stages of CNS drug discovery, outlining the particular requirements and obstacles for CNS drugs Addresses safety concerns and future drug targets Provides succinct background information about the major CNS diseases Examples of specific drugs are used throughout to describe the development of a new drug from conception to clinical use and post-market surveillance Primary reasons for drug failure are given for each stage

Cancer Drug Design And Discovery
Author: Stephen Neidle
Publisher: Academic Press
Release Date: 2013-09-30
Pages: 640
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources

Drug Discovery And Development  Volume 1
Author: Mukund S. Chorghade
Publisher: John Wiley & Sons
Release Date: 2006-07-18
Pages: 476
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This two volume set provides a comprehensive account of the entiresequence of operations involved in discovering a drug through theactual delivery of the drug to clinicians and medicalpractitioners. Includes case studies of the discovery of erythromycin analogs(antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment andmanagement of bacterial infections, Parkinson's disease, psoriasis,ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics The first volume of this set thoroughly describesconceptualizing a drug, creating a library of candidates fortesting, screening those candidates for in vitro and in vivoactivity, conducting and analyzing the results of clinical trials,and revising the drug as necessary.

Drug Discovery And Development   E Book
Author: Raymond G Hill
Publisher: Elsevier Health Sciences
Release Date: 2012-07-20
Pages: 368
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Genomics In Drug Discovery And Development
Author: Dimitri Semizarov
Publisher: John Wiley & Sons
Release Date: 2008-11-03
Pages: 480
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

Flow Cytometry In Drug Discovery And Development
Author: Virginia Litwin
Publisher: John Wiley & Sons
Release Date: 2011-04-20
Pages: 360
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

Medicinal Chemistry And Drug Discovery  Drug Discovery And Drug Development
Author: Alfred Burger
Publisher:
Release Date: 2003
Pages:
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Physico Chemical Methods In Drug Discovery And Development
Author: Zoran Mandic
Publisher: IAPC Publishing
Release Date: 2012
Pages: 482
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Smith And Williams  Introduction To The Principles Of Drug Design And Action
Author: H. Jphn Smith
Publisher: CRC Press
Release Date: 2005-10-10
Pages: 720
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio

Chemical Biology
Author: Natanya Civjan
Publisher: John Wiley & Sons
Release Date: 2012-08-07
Pages: 524
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Optimization In Drug Discovery
Author: Zhengyin Yan
Publisher: Springer Science & Business Media
Release Date: 2004
Pages: 418
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorption, distribution, metabolism, elimination and toxicity issues. Lead optimization in drug discovery, a process of attempting to uncover and correct these defects, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. This book provides the assays utilized in drug discovery to rapidly screen for compounds with favorable drug-like properties. A total of 25 chapters, contributed by many experts in the field, cover a wide spectrum of subjects including physicochemical properties, absorption, plasma binding, metabolism, drug interactions, and toxicity, making this an essential book for all pharmacologists and pharmaceutical scientists.