NEW YORK TIMES BEST SELLER • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY: NPR, The New York Times Book Review, Time, Wall Street Journal, Washington Post • The McKinsey Business Book of the Year The full inside story of the breathtaking rise and shocking collapse of Theranos, the one-time multibillion-dollar biotech startup founded by Elizabeth Holmes—now the subject of the HBO documentary The Inventor—by the prize-winning journalist who first broke the story and pursued it to the end. “The story is even crazier than I expected, and I found myself unable to put it down once I started. This book has everything: elaborate scams, corporate intrigue, magazine cover stories, ruined family relationships, and the demise of a company once valued at nearly $10 billion.” —Bill Gates In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup “unicorn” promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.7 billion. There was just one problem: The technology didn’t work. A riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley.
bad blood secrets and lies online
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Start-Ups, Pivots and Pop-Ups is a must read for anyone with a business idea and the desire to be successful. It gives the reader the skills and knowledge to survive in today's innovation and entrepreneurial-focused world. This book is about starting a business. It's about putting your toe in the entrepreneurial water - perhaps through doing a short term business gig or a pop-up business - and then seeing what happens. It shows you how to listen to the customer and work out why failures may happen, and when they do, you'll learn how to deal with them and create a new business that is robust and ready to grow. Start-Ups, Pivots and Pop-Ups shows you the best ways of starting, testing and growing a business. It shares the stories, experience and insights of those who've done it, and explains how to innovate, trial, refine and succeed. Even if your business idea struggles, you'll find out how to learn so much that you'll pivot your business, try again and then win big time. You'll learn from a range of organizations including abnormal beauty company Deciem, Leon fast-food, Triumph lingerie, New York fashion tech Nineteenth Amendment, Brew Dog beer, Cambridge Satchels, Allbirds, and the Cornish Seaweed Company.
A fierce, honest, elegant and often hilarious debunking of the great fallacies that drive modern medicine. 'A deeply fascinating and rousing book' Mail on Sunday. 'What makes this book a delightful, if unsettling read, is not just O'Mahony's scholarly and witty prose, but also his brutal honesty' The Times. Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be 'conquered' ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.
The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline, as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerate the time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. This book aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies, which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. This book serves as a reference to drug developers, IVD providers, clinical labs, healthcare givers, academicians, and researchers for best practices to help increase the probability of success in drug development and improve patient management. Provides the unique insight of an expert with extensive experience in diagnostics and clinical laboratory on one side and drug discovery and development on the other side Addresses the challenges of drug development and precision medicine and suggests how to eliminate or mitigate these challenges through better utilization of biomarkers and diagnostics in drug development and patient management Features case studies and real-life examples from different classes of biomarkers on different platforms for different therapeutic areas and includes more than 200 illustrations
The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.
"I'm not saying this is Sawyer's fault," the prim and proper one said delicately. "But." Eighteen-year-old auto mechanic Sawyer Taft did not expect her estranged grandmother to show up at her apartment door and offer her a six-figure contract to participate in debutante season. And she definitely never imagined she would accept. But when she realizes that immersing herself in her grandmother's "society" might mean discovering the answer to the biggest mystery of her life-her father's identity-she signs on the dotted line and braces herself for a year of makeovers, big dresses, bigger egos, and a whole lot of bless your heart. The one thing she doesn't expect to find is friendship, but as she's drawn into a group of debutantes with scandalous, dangerous secrets of their own, Sawyer quickly discovers that her family isn't the only mainstay of high society with skeletons in their closet. There are people in her grandmother's glittering world who are not what they appear, and no one wants Sawyer poking her nose into the past. As she navigates the twisted relationships between her new friends and their powerful parents, Sawyer's search for the truth about her own origins is just the beginning. Set in the world of debutante balls, grand estates and rolling green hills, Little White Lies combines a charming setting, a classic fish-out-of-water story, and the sort of layered mystery only author Jennifer Lynn Barnes can pull off.
Besides the fact that their kids all attend the same fashionable Brooklyn Heights private school, Bess, Robin, Carla, and Alicia have little in common. Thrown together on the tony school’s Diversity Committee, the women impulsively turn their awkward first meeting into a boisterous game of poker. Instead of betting with chips or pocket change, however, they play for intimate secrets about their lives. As the Diversity Commitee meetings become a highly anticipated monthly ritual, the new friends reveal more with each game. Picture-perfect housewife Bess struggles to relate to her surly teenage daughter and judgmental mother. Robin, a single mom, grapples with the truth concerning her child’s real father. Carla, an ambitious doctor, attempts to balance the colossal demands of her family with her dream of owning her own private practice. And to distract herself from her troubled marriage, shy copywriter Alicia fantasizes about an attractive younger colleague. Putting all their cards on the table, the four women grow to rely on one another, bracing for one final showdown. From the Trade Paperback edition.
After years of living in the wild, a teenage girl leads her adoptive family's search-and-rescue operation -- but to find a missing child, she must uncover long-buried secrets from her past. Kira Bennett's earliest memories are of living alone and wild in the woods. She has no idea how long she was on her own or what she had to do to survive, but she remembers the moment that Cady Bennett and one of her search-and-rescue dogs found her. Adopted into the Bennett family, Kira still struggles with human interaction years later, but she excels at the family business: search and rescue. Together with Cady's son, Jude, and their neighbor, Free, Kira works alongside Cady to train the world's most elite search-and-rescue dogs. Someday, all three teenagers hope to put their skills to use, finding the lost and bringing them home. When Cady's estranged father, the enigmatic Bales Bennett, tracks his daughter down and asks for her help in locating a missing child -- one of several visitors who has disappeared in the Sierra Glades National Park in the past twelve months -- the teens find themselves on the front lines sooner than they could have ever expected. As the search through seven hundred and fifty thousand acres of unbridled wilderness intensifies, Kira becomes obsessed with finding the missing child. She knows all too well what it's like to be lost in the wilderness, fighting for survival, alone. But this case isn't simple. There is more afoot than a single missing girl, and Kira's memories threaten to overwhelm her at every turn. As the danger mounts and long-held family secrets come to light, Kira is forced to question everything she thought she knew about her adopted family, her true nature, and her past.