anti angiogenesis drug discovery and development

Anti Angiogenesis Drug Discovery And Development
Author: Atta-ur- Rahman
Publisher: Bentham Science Publishers
Release Date: 2011
Pages: 187
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to"

Anti Angiogenesis Drug Discovery And Development  Volume 4
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2019-06-10
Pages: 242
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.This volume brings together 5 reviews on the following topics:- Retinal angiogenesis- Effects of brief daily EMF therapy on tumor growths- Evolution of the role of angiogenesis in cancer treatments over six decades- Anti-angiogenesis drugs- Anti-angiogenesis therapy for multiple sclerosis- Update on the link between angiogenesis and portal hypertension"

Anti Angiogenesis Drug Discovery And Development
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2016-10-06
Pages: 233
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. This volume brings together 5 reviews on these topics: -Beta-blockers for treating premature retinopathy -Anti-angiogenic activity of disintegrin-based, synthetic cyclic KTS peptides -Anti-angiogenic therapy of lung cancer -Oral anti-angiogenic therapy for NSCLC -Angiogenesis in hepatocellular carcinoma

Anti Angiogenesis Drug Discovery And Development  Volume 5
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2020-10-05
Pages: 212
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Anti Angiogenesis Drug Discovery And Development
Author: Atta-ur-Rahman
Publisher: Elsevier
Release Date: 2015-06-16
Pages: 326
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. Edited and written by leading experts in angiogenesis drug development Reviews recent advances in the field, such as coverage of anti-angiogenetic drugs in ovarian cancer Reports current strategies and future outlook for anti-angiogenic therapy and cardiovascular diseases

Anti Angiogenesis Drug Discovery And Development  Volume 4
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2019-06-10
Pages: 242
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.This volume brings together 5 reviews on the following topics:- Retinal angiogenesis- Effects of brief daily EMF therapy on tumor growths- Evolution of the role of angiogenesis in cancer treatments over six decades- Anti-angiogenesis drugs- Anti-angiogenesis therapy for multiple sclerosis- Update on the link between angiogenesis and portal hypertension"

Principles Of Anticancer Drug Development
Author: Elizabeth Garrett-Mayer
Publisher: Springer Science & Business Media
Release Date: 2010-12-29
Pages: 674
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Antiangiogenic Agents In Cancer Therapy
Author: Beverly A. Teicher
Publisher: Springer Science & Business Media
Release Date: 2008-01-08
Pages: 559
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Frontiers In Anti Cancer Drug Discovery  Volume  1
Author: Atta-ur- Rahman
Publisher: Bentham Science Publishers
Release Date: 2011-02-14
Pages: 779
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"Frontiers in Anti-Cancer Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug di

Apoptosis  Senescence And Cancer
Author: David A. Gewirtz
Publisher: Springer Science & Business Media
Release Date: 2007-12-17
Pages: 599
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.

Gene Therapy For Cancer
Author: Kelly K. Hunt
Publisher: Springer Science & Business Media
Release Date: 2007-10-26
Pages: 469
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Frontiers In Anti Cancer Drug Discovery Volume 10
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Release Date: 2019-05-31
Pages: 252
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry,in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The tenth volume of the series features chapters covering the following topics: - Challenges in the Management of Hepatoblastoma - The Emerging Role of Monocarboxylate Transporter-1 in Cancer - In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery - Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers - Polyphenols and Cancer - Glioblastoma Multiforme - Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy.

Drug Discovery And Development   E Book
Author: Raymond G Hill
Publisher: Elsevier Health Sciences
Release Date: 2012-07-20
Pages: 368
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

CNS Cancer
Author: Erwin G. Van Meir
Publisher: Springer Science & Business Media
Release Date: 2009-08-15
Pages: 1284
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Molecular Targeting In Oncology
Author: Howard L. Kaufman
Publisher: Springer Science & Business Media
Release Date: 2007-12-26
Pages: 728
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

Drug Discovery And Evaluation  Pharmacological Assays
Author: Hans G. Vogel
Publisher: Springer Science & Business Media
Release Date: 2002-06-13
Pages: 1408
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

Anti Angiogenic Functional And Medicinal Foods
Author: Jack N. Losso
Publisher: CRC Press
Release Date: 2007-04-05
Pages: 736
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The ability to regulate and manipulate the generation or remodeling of blood vessels is key to the successful treatment of many chronic diseases, both oncological and non-oncological. Several bioactive compounds present in human diets are now known to exert an inhibitive effect on the either the signaling or construction of new blood vessels. The identification and characterization of these anti-angiogenic molecules opens a new avenue for the research and production of functional and medicinal foods with far reaching implications for the food-based treatment of chronic degenerative disease. Drawing from an extensive list of esteemed international contributors, Anti-Angiogenic Functional and Medicinal Foods explores the history and scope of the use of conventional foods, nutraceuticals, and health products in North America, Europe, the Middle East, Asia, India, Australia, and New Zealand. Recent advancements in proteomics, genomics, and toxicogenomics give us a far more detailed picture of the molecular basis of nutrition and systems toxicology. Explaining the role of angiogenesis in various chronic diseases, individual chapters consider endothelial cell responses, the mechanism of the angiogenic cascade, and the angiogenic function involved in tumors, cardiovascular disease, inflammatory arthritis, and obesity. A collection of chapters studies specific foods and their functional bioactive compounds such as the effects of edible berry anthocyanins, various Chinese medicinal foods, dietary flavonoids, probiotics, shark cartilage, EPA and DHA, and marine polysaccharides. The book concludes with a discussion of the challenges faced during the development and delivery of anti-angiogenic functional food products. Presenting the current research and state of the science, Anti-Angiogenic Functional and Medicinal Foods provides researchers, scientists, clinical nutritionists, and oncologists with a valuable reference to this important and growing mode of therapy.

The 25th Congress Of The International Association For Breast Cancer Research
Author: International association for breast cancer research. congress
Publisher: IOS Press
Release Date: 2006
Pages: 76
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

"In this publication, youll find the abstracts of the presentations of the Congress of the International Association for Breast Cancer Research. This international Congress brings together basic and clinical researchers from around the globe who are investigating the molecular basis of breast cancer. The theme for this meeting is Personalized Breast Cancer Therapy. Given the rapid advances that are being made in basic and applied breast cancer research, this theme is particularly topical and covers a number of areas of general interest to breast cancer researchers including sessions on pathology and molecular profiling of breast tumors, signal transduction, receptors and hormones, tumor microenvironment, cancer stem cells and clinical therapeutics. The publication is of interest to scientists, clinical oncologists, regulators, breast cancer advocates, and representatives of the biotechnology and health care industries."

Basic And Clinical Pharmacology  11th Edition
Author: Bertram G. Katzung
Publisher: McGraw Hill Professional
Release Date: 2009-08-12
Pages: 1232
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

The most trusted and up-to-date pharmacology text in medicine -- completely redesigned to make the learning process even more interesting and efficient 5 Star Doody's Review! "This is the most widely used textbook for teaching pharmacology to health professionals. This 11th edition is far superior to any previous editions....The authors' goals are to provide a complete, authoritative, current, and readable textbook of pharmacology for students in health sciences. Testimony to their success is the widespread use of this work as required textbook for pharmacology courses around the world. This book is used extensively by thousands of medical, pharmacy, podiatry, nursing, and other health professions students to study pharmacology. Likewise, it remains a valuable resource for residents and practicing physicians....I continue to use this book as a required resource for all courses that I teach to medical, nursing, and allied health students. It is authoritative, readable, and supported by numerous learning tools."--Doody's Review Service Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field’s most current, authoritative, and comprehensive textbook. To be as clinically relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects. Coverage that spans every important aspect of medical pharmacology: Basic Principles Autonomic Drugs Cardiovascular-Renal Drugs Drugs with Important Actions on Smooth Muscle Drugs that Act in the Central Nervous System Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout Endocrine Drugs Chemotherapeutic Drugs Toxicology NEW to this edition: Full-color presentation, including 300+ illustrations Case studies introduce clinical problems in many chapters Drug summary tables for key information in comparative context Descriptions of important newly released drugs, including new immunopharmacologic agents Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters

Cytokines In The Genesis And Treatment Of Cancer
Author: Michael A. Caligiuri
Publisher: Springer Science & Business Media
Release Date: 2007-09-19
Pages: 482
ISBN:
Available Language: English, Spanish, And French
EBOOK SYNOPSIS:

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.